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dc.contributor.authorLanduyt, J.
dc.contributor.authorDebackere, M.
dc.contributor.authorVercruysse, J.
dc.contributor.authorMcKellar, Quintin
dc.date.accessioned2013-07-23T15:17:40Z
dc.date.available2013-07-23T15:17:40Z
dc.date.issued1995-06
dc.identifier.citationLanduyt , J , Debackere , M , Vercruysse , J & McKellar , Q 1995 , ' The influence of a heavy infection with sensitive and resistant strains of Ostertagia circumcincta and with Trichostrongylus colubriformis on the pharmacokinetics of febantel in lambs ' Journal of Veterinary Pharmacology and Therapeutics , vol. 18 , no. 3 , pp. 180-186 . https://doi.org/10.1111/j.1365-2885.1995.tb00576.x
dc.identifier.otherPURE: 1431702
dc.identifier.otherPURE UUID: c11ada77-3a60-4a61-850e-d6949e1c0514
dc.identifier.otherBibtex: urn:487fd47d683d2f215fd29fe66d665f1d
dc.identifier.otherScopus: 0029009723
dc.identifier.urihttp://hdl.handle.net/2299/11153
dc.description.abstractPlasma concentrations of febantel and its major metabolites, fenbendazole, oxfen-dazole and fenbendazole sulphone, were determined after oral administration of 7.5 mg/kg febantel in lambs before and 28 days after infection with 100 000 L3 larvae of a benzimidazole (BZ)- sensitive or BZ-resistant strain of Ostertagia circumcincta or with 75 000 L3 larvae of a BZ- sensitive Trichostrongylus colubriformis strain. The febantel concentrations were always low, and in only a few samples were higher than the limit of detection. A mean decrease in the area under the curve (AUC) for the three metabolites of 10.2%, 16.4% and 4.9% in lambs infected, respectively, with BZ-sensitive O. circumcincta, BZ-resistant O. circumcincta and T. colubriformis was observed. The Cmax for all the metabolites was higher in the BZ-sensitive O. circumcincta group than in the naive sheep, while the Tmax occurred earlier. The Cmax and the Tmax values for all the metabolites were lower in the BZ-resistant O. circumcincta group than in their own naive controls. In the T. colubriformis group the Cmax values of the metabolites were lower and the Tmax occurred much later.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.titleThe influence of a heavy infection with sensitive and resistant strains of Ostertagia circumcincta and with Trichostrongylus colubriformis on the pharmacokinetics of febantel in lambsen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1111/j.1365-2885.1995.tb00576.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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