Show simple item record

dc.contributor.authorBarrett, M.
dc.contributor.authorJackson, F.
dc.contributor.authorPatterson, M.
dc.contributor.authorJackson, E.
dc.contributor.authorMcKellar, Quintin
dc.date.accessioned2013-07-25T13:02:43Z
dc.date.available2013-07-25T13:02:43Z
dc.date.issued1998-03
dc.identifier.citationBarrett , M , Jackson , F , Patterson , M , Jackson , E & McKellar , Q 1998 , ' Comparative field evaluation of divided-dosing and reduced feed intake upon treatment efficacy against resistant isolates of Teladorsagia circumcincta in sheep and goats ' , Research in Veterinary Science , vol. 64 , no. 2 , pp. 101-104 . https://doi.org/10.1016/S0034-5288(98)90003-0
dc.identifier.otherPURE: 1422073
dc.identifier.otherPURE UUID: 3bdd7927-03c2-45bd-887e-18d998e21010
dc.identifier.otherBibtex: urn:44c7f90957174a5a1f2a4ebf3d11be1a
dc.identifier.otherScopus: 0031947288
dc.identifier.urihttp://hdl.handle.net/2299/11186
dc.description.abstractThe effects of modifying drug administration and food intake upon the efficacy of fenbendazole against resistant isolates of Teladorsagia (Ostertagia) circumcincta were investigated using naturally infected sheep and goats. Administration of the manufacturer's recommended dose (MRD) as two 2.5 mg kg(-1) bodyweight doses divided by a 12-hour interval resulted in an apparent increase in efficacy of over 28 per cent compared with conventionally treated sheep. Withholding feed for 24 hours before treatment at the MRD resulted in respective increases of 39.7 per cent (P<0.05) and 25.2 per cent compared with conventionally treated sheep and goats. A combination of food withdrawal and divided dosing did not further increase treatment efficacy in goats. It is suggested that withholding feed, divided-dosing or combining these methods may extend the useful life of the broad spectrum class of anthelmintics.en
dc.format.extent4
dc.language.isoeng
dc.relation.ispartofResearch in Veterinary Science
dc.subjectANTHELMINTIC RESISTANCE
dc.subjectOSTERTAGIA-CIRCUMCINCTA
dc.subjectTRICHOSTRONGYLUS-COLUBRIFORMIS
dc.subjectOXFENDAZOLE
dc.subjectDISPOSITION
dc.subjectNEMATODES
dc.subjectSCOTLAND
dc.subjectPHARMACOKINETICS
dc.subjectINFECTIONS
dc.subjectREDUCTION
dc.titleComparative field evaluation of divided-dosing and reduced feed intake upon treatment efficacy against resistant isolates of Teladorsagia circumcincta in sheep and goatsen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
dcterms.dateAccepted1998-03
rioxxterms.versionofrecordhttps://doi.org/10.1016/S0034-5288(98)90003-0
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record