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dc.contributor.authorReid, M.L.
dc.contributor.authorBenaouda, F.
dc.contributor.authorKhengar, Rajeshree H.
dc.contributor.authorJones, S.A.
dc.contributor.authorBrown, Marc
dc.date.accessioned2013-07-25T13:47:41Z
dc.date.available2013-07-25T13:47:41Z
dc.date.issued2013-08-16
dc.identifier.citationReid , M L , Benaouda , F , Khengar , R H , Jones , S A & Brown , M 2013 , ' Topical corticosteroid delivery into human skin using hydrofluoroalkane metered dose aerosol sprays ' , International Journal of Pharmaceutics , vol. 452 , no. 1-2 , pp. 157-165 . https://doi.org/10.1016/j.ijpharm.2013.04.083
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 2042384
dc.identifier.otherPURE UUID: db7f4e19-397f-4e8d-90e6-803e65abb7a2
dc.identifier.otherScopus: 84884201864
dc.identifier.urihttp://hdl.handle.net/2299/11191
dc.description.abstractDrug loaded hydrofluoroalkane (HFA) sprays can generate effective pharmaceutical formulations, but a deeper understanding of the manner in which these dynamic systems drive the process of in situ semi-solid dosage form assembly is required. The aim of this study was to investigate the effect of the matrix assembly and composition on drug localisation in human skin. Comparing the characteristics of sprays constituting HFA 134a, ethanol (EtOH), poly(vinyl pyrrolidone) K90, isopropyl myristate (IPM), and poly(ethylene glycol) (PEG) demonstrated that the addition of non-volatile solvents acted to delay EtOH evaporation, control the degree of drug saturation (DS) and enhance the corticosteroid delivery from HFA spray formulations. In a dose matched skin penetration study the HFA sprays containing only EtOH as a co-solvent delivered 2.1 g BMV (DS 13.5) into the tissue, adding IPM to the EtOH HFA delivered 4.03 g BMV (DS 11.2), whist adding PEG to the EtOH HFA delivered 6.1 g BMV (DS 0.3). Compared to commercial cream (delivering 0.91 g BMV) the EtOH/PEG HFA spray deposited over 6 times (p < 0.05) more drug into the skin. Post spray deposition characterisation of the semi-solid suggested that the superior performance of the EtOH/PEG HFA spray was a consequence of retarding EtOH evaporation and presenting the drug in an EtOH rich PEG residual phase, which promoted BMV passage through the SC and into epidermis.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.subjectSupersaturation; Volatile evaporation; HFA spray; Skin delivery; Corticosteroids
dc.titleTopical corticosteroid delivery into human skin using hydrofluoroalkane metered dose aerosol spraysen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionToxicology
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2013-08-16
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2013.04.083
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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