Moisture uptake of polyoxyethylene glycol glycerides used as matrices for drug delivery : kinetic modelling and practical implications
Author
Qi, Sheng
Belton, Peter
McAuley, William James
Codoni, Dorothy
Darji, Neerav
Attention
2299/11196
Abstract
Gelucire 50/13, a polyoxyethylene glycol glyceride mixture, has been widely used in drug delivery, but its moisture uptake behaviour is still poorly understood. In this study, the effects of relative humidity, temperature, and drug incorporation on the moisture uptake of Gelucire are reported in relation to their practical implications for preparation of solid dispersions using this material