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dc.contributor.authorJaffari, Sara
dc.contributor.authorForbes, Ben
dc.contributor.authorCollins, Elizabeth
dc.contributor.authorBarlow, David J.
dc.contributor.authorMartin, Gary P.
dc.contributor.authorMurnane, Darragh
dc.date.accessioned2013-07-25T15:02:43Z
dc.date.available2013-07-25T15:02:43Z
dc.date.issued2013-04
dc.identifier.citationJaffari , S , Forbes , B , Collins , E , Barlow , D J , Martin , G P & Murnane , D 2013 , ' Rapid characterisation of the inherent dispersibility of respirable powders using dry dispersion laser diffraction ' , International Journal of Pharmaceutics , vol. 447 , no. 1-2 , pp. 124-131 . https://doi.org/10.1016/j.ijpharm.2013.02.034
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 2053717
dc.identifier.otherPURE UUID: 50a0dd6b-cc39-4413-a4f5-73fb440df368
dc.identifier.otherScopus: 84875060101
dc.identifier.urihttp://hdl.handle.net/2299/11199
dc.descriptionPublished as an open access article by Elsevier. Sponsored free access: http://www.sciencedirect.com/science/article/pii/S0378517313001695#
dc.description.abstractUnderstanding and controlling powder de-agglomeration is of great importance in the development of dry powder inhaler (DPI) products. Dry dispersion laser diffraction measures particle size readily under controlled dispersing conditions, but has not been exploited fully to characterise inherent powder dispersibility. The aim of the study was to utilise particle size-dispersing pressure titration curves to characterise powder cohesivity and ease of de-agglomeration. Seven inhaled drug/excipient powders (beclometasone dipropionate, budesonide, fluticasone propionate, lactohale 300, salbutamol base, salmeterol xinafoate and tofimilast) were subjected to a range of dispersing pressures (0.2–4.5 Bar) in the Sympatec HELOS/RODOS laser diffractometer and particle size measurements were recorded. Particle size-primary pressure data were used to determine the pressures required for complete deagglomeration. The latter were employed as an index of the cohesive strength of the powder (critical primary pressure; CPP), and the curves were modelled empirically to derive the pressure required for 50% de-agglomeration (DA50). The powders presented a range of CPP (1.0–3.5 Bar) and DA50 (0.23–1.45 Bar) which appeared to be characteristic for different mechanisms of powder de-agglomeration. This approach has utility as a rapid pre-formulation tool to measure inherent powder dispersibility, in order to direct the development strategy of DPI products.en
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.titleRapid characterisation of the inherent dispersibility of respirable powders using dry dispersion laser diffractionen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionAirway Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2013.02.034
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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