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dc.contributor.authorMerchant, Hamid A.
dc.contributor.authorMcConnell, Emma L.
dc.contributor.authorLiu, Fang
dc.contributor.authorRamaswamy, Chandrasekaran
dc.contributor.authorKulkarni, Rucha P.
dc.contributor.authorBasit, Abdul W.
dc.contributor.authorMurdan, Sudaxshina
dc.date.accessioned2013-08-13T14:00:03Z
dc.date.available2013-08-13T14:00:03Z
dc.date.issued2011-01-18
dc.identifier.citationMerchant , H A , McConnell , E L , Liu , F , Ramaswamy , C , Kulkarni , R P , Basit , A W & Murdan , S 2011 , ' Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development ' , European Journal of Pharmaceutical Sciences , vol. 42 , no. 1-2 , pp. 3-10 . https://doi.org/10.1016/j.ejps.2010.09.019
dc.identifier.issn1879-0720
dc.identifier.otherPURE: 2097789
dc.identifier.otherPURE UUID: 445f4067-46f2-4b60-90f8-e69d9862866c
dc.identifier.otherPubMed: 20932902
dc.identifier.otherScopus: 78650678024
dc.identifier.urihttp://hdl.handle.net/2299/11340
dc.descriptionCopyright © 2010 Elsevier B.V. All rights reserved.
dc.description.abstractLaboratory animals are often used in drug delivery and research. However, basic information about their gastrointestinal pH, fluid volume, and lymphoid tissue is not completely known. We have investigated these post-mortem in healthy guinea pigs, rabbits and pigs, to assess their suitability for pre-clinical studies by comparing the results with reported human literature. The mean gastric pH (fed ad libitum) was 2.9 and 4.4 in guinea pig and pig, respectively. In contrast, a very low pH (1.6) was recorded in the rabbits. The small intestinal pH was found in the range of 6.4-7.4 in the guinea pigs and rabbits, whereas lower pH (6.1-6.7) was recorded in the pig, which may have consequences for ionisable or pH responsive systems when tested in pig. A relatively lower pH than in the small intestine was found in the caecum (6.0-6.4) and colon (6.1-6.6) of the guinea pig, rabbit and the pig. The water content in the gastrointestinal tract of guinea pig, rabbit and pig was 51g, 153g and 1546g, respectively. When normalized to the body weight, the guinea pig, had larger amounts of water compared to the rabbit and the pig (guinea pig>rabbit>pig); in contrast, a reverse order was found when normalized to per unit length of the gut (guinea pig)en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciences
dc.subjectBody Fluids
dc.subjectModels, Animal
dc.subjectSwine
dc.subjectAnimals
dc.subjectGuinea Pigs
dc.subjectHydrogen-Ion Concentration
dc.subjectRabbits
dc.subjectDrug Design
dc.subjectLymphoid Tissue
dc.subjectDrug Evaluation, Preclinical
dc.subjectSpecies Specificity
dc.subjectMale
dc.subjectGastrointestinal Tract
dc.titleAssessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug developmenten
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2011-01-18
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ejps.2010.09.019
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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