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dc.contributor.authorIbekwe, Valentine C.
dc.contributor.authorLiu, Fang
dc.contributor.authorFadda, Hala M.
dc.contributor.authorKhela, Mandeep K.
dc.contributor.authorEvans, David F.
dc.contributor.authorParsons, Gary E.
dc.contributor.authorBasit, Abdul W.
dc.date.accessioned2013-08-13T14:00:05Z
dc.date.available2013-08-13T14:00:05Z
dc.date.issued2006-12
dc.identifier.citationIbekwe , V C , Liu , F , Fadda , H M , Khela , M K , Evans , D F , Parsons , G E & Basit , A W 2006 , ' An investigation into the in vivo performance variability of pH responsive polymers for ileo-colonic drug delivery using gamma scintigraphy in humans ' , Journal of Pharmaceutical Sciences , vol. 95 , no. 12 , pp. 2760-6 . https://doi.org/10.1002/jps.20742
dc.identifier.issn0022-3549
dc.identifier.otherPURE: 2097838
dc.identifier.otherPURE UUID: d958b449-7435-4b42-b5f4-bc02e1605924
dc.identifier.otherPubMed: 16917845
dc.identifier.otherScopus: 33846244273
dc.identifier.urihttp://hdl.handle.net/2299/11341
dc.description(c) 2006 Wiley-Liss, Inc. and the American Pharmacists Association
dc.description.abstractGastrointestinal performance of tablets coated with pH responsive acrylic polymers (Eudragit) was investigated in human volunteers. Tablet cores were coated with Eudragit S dissolved in ethanol (organic), Eudragit S aqueous dispersion (aqueous), or Eudragit FS aqueous dispersion. Eight fasted volunteers received the tablets in a two-way crossover design-treatment 1: Eudragit S (organic) and Eudragit FS coated tablets; treatment 2: Eudragit S (aqueous) and Eudragit FS coated tablets. Eudragit FS coated tablets were included in both treatments to assess its intra-subject performance. Tablets were radiolabelled and followed by gamma scintigraphy; the disintegration times and positions were recorded. Tablets coated with Eudragit S (aqueous) disintegrated in all volunteers mainly in the proximal to mid small intestine. Eudragit S (organic) tablets failed to disintegrate in three out of eight volunteers, while disintegration was in the ileo-caecal junction and ascending colon in all others. Eudragit FS coated tablets disintegrated in 14 out of the 16 administrations. The Eudragit FS coated tablets that did disintegrate exhibited consistent intra- and inter-subject performance, with the site of disintegration focused on the ileo-caecal junction and ascending colon. These in vivo results correlate better with our published in vitro dissolution data in physiological bicarbonate buffers compared to phosphate buffers.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofJournal of Pharmaceutical Sciences
dc.subjectDrug Delivery Systems
dc.subjectHumans
dc.subjectHydrogen-Ion Concentration
dc.subjectPolymethacrylic Acids
dc.subjectIleum
dc.subjectRadionuclide Imaging
dc.subjectIndium Radioisotopes
dc.subjectTechnetium
dc.subjectColon
dc.subjectAdult
dc.subjectPrednisolone
dc.subjectTablets, Enteric-Coated
dc.subjectPolymers
dc.subjectGastrointestinal Transit
dc.subjectMale
dc.titleAn investigation into the in vivo performance variability of pH responsive polymers for ileo-colonic drug delivery using gamma scintigraphy in humansen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.description.statusPeer reviewed
dc.relation.school
dcterms.dateAccepted2006-12
rioxxterms.versionofrecordhttps://doi.org/10.1002/jps.20742
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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