University of Hertfordshire Research Archive

        JavaScript is disabled for your browser. Some features of this site may not work without it.

        Browse

        All of UHRABy Issue DateAuthorsTitlesThis CollectionBy Issue DateAuthorsTitles

        Arkivum Files

        My Downloads
        View Item 
        • UHRA Home
        • University of Hertfordshire
        • Research publications
        • View Item
        • UHRA Home
        • University of Hertfordshire
        • Research publications
        • View Item

        Pharmacokinetics and tissue disposition of danofloxacin in sheep

        Author
        McKellar, Quintin
        Gibson, I.F.
        McCormack, R.Z.
        Attention
        2299/11383
        Abstract
        The plasma pharmacokinetics of danofloxacin administered at 1.25 mg kg(-1) body weight by the intravenous and intramuscular routes were determined in sheep. Tissue distribution was also determined following administration by the intramuscular route at 1.25 mg kg(-1) body weight. Danofloxacin had a large volume of distribution at steady state (V-dss) of 2.76 +/- 0.16 h (mean +/- S.E.M.) L kg(-1), an elimination half-life ((1/2 beta)) of 335 +/- 0.23 h, and a body clearance (C1) of 0.63 +/- 0.04 L kg(-1) h(-1). Following intramuscular administration it achieved a maximum concentration (C-max) of 0.32 +/- 0.02 mu g mL(-1) at 1.23 +/- 0.34 h (t(max)) and had a mean residence time (MRT) of 5.45 +/- 0.19 h. Danofloxacin had an absolute bioavailability (F) of 95.71 +/- 4.41% and a mean absorption time (MAT) of 0.81 +/- 0.20 h following intramuscular administration. Mean plasma concentrations of > 0.06 mu g mL(-1) were maintained for more than 8 h following intravenous and intramuscular administration. Following intramuscular administration highest concentrations were measured in plasma (0.43 +/- 0.04 mu g mL(-1)), lung (1.51 +/- 0.18 mu g g(-1)), and interdigital skin (0.64 +/- 0.18 mu g g(-1)) at 1 h, duodenal contents (0.81 +/- 0.40 mu g mL(-1)), lymph nodes (4.61 +/- 0.35 mu g g(-1)), and brain (0.06 +/- 0.00 mu g mL(-1)) at 2 h, jejunal (10.50 +/- 4.31 mu g mL(-1)) and ileal (5.25 +/- 1.67 mu g mL(-1)) contents at 4 h, and colonic contents (8.94 +/- 0.65 mu g mL(-1)) at 8 h. (C) 1998 John Wiley & Sons, Ltd.
        Publication date
        1998-03
        Published in
        Biopharmaceutics and Drug Disposition
        Published version
        https://doi.org/10.1002/(SICI)1099-081X(199803)19:2<123::AID-BDD89>3.0.CO;2-G
        Other links
        http://hdl.handle.net/2299/11383
        Metadata
        Show full item record
        Keep in touch

        © 2019 University of Hertfordshire

        I want to...

        • Apply for a course
        • Download a Prospectus
        • Find a job at the University
        • Make a complaint
        • Contact the Press Office

        Go to...

        • Accommodation booking
        • Your student record
        • Bayfordbury
        • KASPAR
        • UH Arts

        The small print

        • Terms of use
        • Privacy and cookies
        • Criminal Finances Act 2017
        • Modern Slavery Act 2015
        • Sitemap

        Find/Contact us

        • T: +44 (0)1707 284000
        • E: ask@herts.ac.uk
        • Where to find us
        • Parking
        • hr
        • qaa
        • stonewall
        • AMBA
        • ECU Race Charter
        • disability confident
        • AthenaSwan