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dc.contributor.authorScott, I.
dc.contributor.authorStear, M.J.
dc.contributor.authorIrvine, J.
dc.contributor.authorDick, A.
dc.contributor.authorWallace, D.S.
dc.contributor.authorMcKellar, Quintin
dc.identifier.citationScott , I , Stear , M J , Irvine , J , Dick , A , Wallace , D S & McKellar , Q 1998 , ' Changes in the zymogenic cell populations of the abomasa of sheep infected with Haemonchus contortus ' , Parasitology , vol. 116 , no. 06 , pp. 569-577 .
dc.identifier.otherPURE: 1421317
dc.identifier.otherPURE UUID: 7072c135-cc61-4f3b-9059-a20123b0d105
dc.identifier.otherBibtex: urn:d1f128be0c1b40b430db71ba8e279987
dc.identifier.otherScopus: 0031838510
dc.description.abstractThe effects of dietary urea supplementation and of a 10-week trickle infection regime, simulating chronic exposure to Haemonchus contortus, on the zymogenic population of the abomasa of Hampshire Down lambs was examined, dt necropsy a variety of parameters including plasma pepsinogen concentrations, the wet weights of abomasal fundic mucosal pieces and the amounts of pepsinogen contained in them, were assessed. Tissue pepsinogen concentration was measured as the total, acid-stable proteolytic activity present in mucosal homogenates, as well as immunohistochemically. The immunohistochemical findings were quantified using computer-aided image analysis. Elevation of plasma pepsinogen concentrations in infected animals was of borderline significance (P = 0.06). The fundic mucosae of infected animals were heavier (P < 0.02) than those of control animals, but there was no overall change in the pepsinogen content of tissues. Immunohistochemistry revealed that infected animals had increased numbers of zymogenic cells, due to mucous cell hyperplasia and the adaptation of cells to produce both mucins and pepsinogen. The pepsinogen content of chief cells, the major source of pepsinogen in uninfected animals, was reduced in infected lambs. Image analysis confirmed that at a mid-point of the mucosa of infected animals there was increased pepsinogen-specific immunoreactivity that corresponded with areas of mucosal hyperplasia. Mucous cell hyperplasia might therefore allow the maintenance of pepsinogen secretion in infected animals even if chief cell output is reduced.en
dc.subjectHaemonchus contortus
dc.subjectpeptic activity
dc.subjectmucous cell hyperplasia
dc.titleChanges in the zymogenic cell populations of the abomasa of sheep infected with Haemonchus contortusen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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