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dc.contributor.authorIravani, Mahmoud M.
dc.contributor.authorSyed, E.
dc.contributor.authorJackson, M. J.
dc.contributor.authorJohnston, L. C.
dc.contributor.authorSmith, L. A.
dc.contributor.authorJenner, P.
dc.date.accessioned2013-08-22T12:00:00Z
dc.date.available2013-08-22T12:00:00Z
dc.date.issued2005-02
dc.identifier.citationIravani , M M , Syed , E , Jackson , M J , Johnston , L C , Smith , L A & Jenner , P 2005 , ' A modified MPTP treatment regime produces reproducible partial nigrostriatal lesions in common marmosets ' , European Journal of Neuroscience , vol. 21 , no. 4 , pp. 841-854 . https://doi.org/10.1111/j.1460-9568.2005.03915.x
dc.identifier.issn0953-816X
dc.identifier.otherPURE: 735538
dc.identifier.otherPURE UUID: d8b6226d-f1a0-466b-b1f0-41f3c5498c5e
dc.identifier.otherWOS: 000227652600002
dc.identifier.otherScopus: 16244387184
dc.identifier.otherORCID: /0000-0002-4905-9682/work/32997592
dc.identifier.urihttp://hdl.handle.net/2299/11445
dc.description.abstractStandard MPTP treatment regimens in primates result in > 85% destruction of nigral dopaminergic neurons and the onset of marked motor deficits that respond to known symptomatic treatments for Parkinson's disease (PD). The extent of nigral degeneration reflects the late stages of PD rather than events occurring at its onset. We report on a modified MPTP treatment regimen that causes nigral dopaminergic degeneration in common marmosets equivalent to that occurring at the time of initiation of motor symptoms in man. Subcutaneous administration of MPTP 1 mg/kg for 3 consecutive days caused a reproducible 60% loss of nigral tyrosine hydroxylase (TH)-positive cells, which occurred mainly in the calbindin-D-28k-poor nigrosomes with a similar loss of TH-immunoreactivity (TH-ir) in the caudate nucleus and the putamen. The animals showed obvious motor abnormalities with reduced bursts of activity and the onset of motor disability. However, the loss of striatal terminals did not reflect early PD because a greater loss of TH-ir occurred in the caudate nucleus than in the putamen and a marked reduction in TH-ir occurred in striatal patches compared to the matrix. Examination of striatal fibres following a partial MPTP lesion showed a conspicuous increase in the number and the diameter of large branching fibres in the putaminal and to some extent caudatal matrix, pointing to a possible compensatory sprouting of dopaminergic terminals. In addition, these partially lesioned animals did not respond to acute treatment with L-DOPA. This primate partial lesions model may be useful for examining potential neuroprotective or neurorestorative agents for PD.en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Neuroscience
dc.subjectcommon marmosets
dc.subjectMPTP
dc.subjectsubstantia nigra
dc.subjectstriatum
dc.subjectpartial lesion
dc.subjectParkinson's disease
dc.subjectIDIOPATHIC PARKINSONS-DISEASE
dc.subjectSUBSTANTIA-NIGRA
dc.subjectDOPAMINE LOSS
dc.subject1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-TREATED PRIMATES
dc.subjectRHESUS-MONKEY
dc.subjectHUMAN BRAIN
dc.subjectSTRIATUM
dc.subjectNEURONS
dc.subjectPATTERN
dc.subjectMATRIX
dc.titleA modified MPTP treatment regime produces reproducible partial nigrostriatal lesions in common marmosetsen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2005-02
rioxxterms.versionofrecordhttps://doi.org/10.1111/j.1460-9568.2005.03915.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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