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dc.contributor.authorPoliti, M.
dc.contributor.authorPeschel, W.
dc.contributor.authorWilson, N.
dc.contributor.authorZloh, Mire
dc.contributor.authorPrieto, J. M.
dc.contributor.authorHeinrich, M.
dc.identifier.citationPoliti , M , Peschel , W , Wilson , N , Zloh , M , Prieto , J M & Heinrich , M 2008 , ' Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on delta9-THC and delta9-THC-acid ' , Phytochemistry , vol. 69 , no. 2 , pp. 562-70 .
dc.identifier.otherPURE: 1457853
dc.identifier.otherPURE UUID: 486fc2ca-a779-4bdc-937a-2dbb2ddbb54c
dc.identifier.otherPubMed: 17964620
dc.identifier.otherScopus: 37549002467
dc.description.abstractCannabis sativa L. is the source for a whole series of chemically diverse bioactive compounds that are currently under intensive pharmaceutical investigation. In this work, hot and cold water extracts as well as ethanol/water mixtures (tinctures) of cannabis were compared in order to better understand how these extracts differ in their overall composition. NMR analysis and in vitro cell assays of crude extracts and fractions were performed. Manufacturing procedures to produce natural remedies can strongly affect the final composition of the herbal medicines. Temperature and polarity of the solvents used for the extraction resulted to be two factors that affect the total amount of Delta(9)-THC in the extracts and its relative quantity with respect to Delta(9)-THC-acid and other metabolites. Diffusion-edited (1)H NMR (1D DOSY) and (1)H NMR with suppression of the ethanol and water signals were used. With this method it was possible, without any evaporation or separation step, to distinguish between tinctures from different cannabis cultivars. This approach is proposed as a direct analysis of plant tinctures.en
dc.titleDirect NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on delta9-THC and delta9-THC-aciden
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.typeJournal Article/Review

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