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dc.contributor.authorCevher, Erdal
dc.contributor.authorSensoy, Demet
dc.contributor.authorZloh, Mire
dc.contributor.authorMülazimoğlu, Lütfiye
dc.date.accessioned2013-09-02T12:30:01Z
dc.date.available2013-09-02T12:30:01Z
dc.date.issued2008
dc.identifier.citationCevher , E , Sensoy , D , Zloh , M & Mülazimoğlu , L 2008 , ' Preparation and characterisation of natamycin : gamma-cyclodextrin inclusion complex and its evaluation in vaginal mucoadhesive formulations ' , Journal of Pharmaceutical Sciences , vol. 97 , no. 10 , pp. 4319-35 . https://doi.org/10.1002/jps.21312
dc.identifier.issn1520-6017
dc.identifier.otherPURE: 1457822
dc.identifier.otherPURE UUID: 0239d3f9-e7a2-4df3-8938-51a89e5ea685
dc.identifier.otherPubMed: 18288724
dc.identifier.otherScopus: 55749092785
dc.identifier.urihttp://hdl.handle.net/2299/11467
dc.description(c) 2008 Wiley-Liss, Inc. and the American Pharmacists Association
dc.description.abstractNovel formulations of vaginal bioadhesive tablets were prepared where the natamycin was complexed with gamma-cyclodextrin (NT-gamma CyD) to increase the solubility and stability of NT in aqueous solutions and reduce the side effects of the drug without decreasing antimycotic activity. Favourable interactions between the NT and gamma CyD and formation of the 1:1 inclusion complex were observed. The MIC(90) of both NT alone and NT-gamma CyD complexes were below 0.0313 microg mL(-1), suggesting that complexation with gamma CyD has effectively increased the antimycotic activity of NT, thus indicating the clinical usefulness of NT-gamma CyD complexes. The sustained drug release of NT was achieved to over 8 h periods by altering the polymer component of formulations which was responsible for differences in water absorption and erosion behaviour of the tablets. Bioadhesion studies have clearly indicated that enhancement of mucoadhesion was achieved by inclusion of Carbopol 934P and by tailoring the ratio of Carbopol 934P in the formulation, a high mucoadhesion to vaginal mucosa can be achieved. Hence, the formation of complex between NT and gamma CyD and effective combination with polymers attain a bioadhesive and sustained release formulation of NT suitable for vaginal delivery and the effective treatment of Candida infections.en
dc.format.extent17
dc.language.isoeng
dc.relation.ispartofJournal of Pharmaceutical Sciences
dc.titlePreparation and characterisation of natamycin : gamma-cyclodextrin inclusion complex and its evaluation in vaginal mucoadhesive formulationsen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2008
rioxxterms.versionofrecordhttps://doi.org/10.1002/jps.21312
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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