Show simple item record

dc.contributor.authorHarrington, L.S.
dc.contributor.authorAli, F.
dc.contributor.authorMitchell, J.A.
dc.contributor.authorWray, J.
dc.contributor.authorSwales, K.E.
dc.contributor.authorNorling, L.
dc.contributor.authorEvans, R.J.
dc.contributor.authorVial, C.
dc.contributor.authorCarrier, M.J.
dc.identifier.citationHarrington , L S , Ali , F , Mitchell , J A , Wray , J , Swales , K E , Norling , L , Evans , R J , Vial , C & Carrier , M J 2007 , ' Purinergic 2X receptors mediate endothelial dependent vasodilation to ATP ' , Molecular Pharmacology , vol. 72 , no. 5 , pp. 1132-1136 .
dc.identifier.otherPURE: 1744682
dc.identifier.otherPURE UUID: 4a52120e-6600-4372-a085-37de9d344d7c
dc.identifier.otherScopus: 35548951027
dc.description.abstractATP is an important endogenous mediator in the cardiovascular system. It induces endothelium dependent vasodilation, but the precise receptor pathway activated in this response is currently under debate. We have used traditional bioassay techniques to show that ATP-induced vasodilation in mesenteric vessels is endothelium-dependent. Furthermore, ATP-induced vasodilation was inhibited by both suramin and 2′,3′-O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP), consistent with a P2X-, P2X-, or P2X- mediated event and was not potentiated by ivermectin, indicating that these responses were not P2X receptor-mediated. ATP did not induce vasodilation in vessels from P2X mice, confirming an absolute requirement for this receptor. Finally, in pure cell populations of mouse mesenteric artery endothelial cells, we show that P2X mRNA is specifically expressed. However, in line with observations in the brain, the P2X present in endothelial cells does not seem to be recognized by conventional antibodies. Together, these results show that ATP-induced vasodilation is mediated by P2X receptor activation on mesenteric arterial endothelial cells. These observations establish a critical role for P2X receptors in the ATP vasodilator pathway.en
dc.relation.ispartofMolecular Pharmacology
dc.titlePurinergic 2X receptors mediate endothelial dependent vasodilation to ATPen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record