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Discovery and Characterization of Sulfoxaflor, a Novel Insecticide Targeting Sap-Feeding Pests

dc.contributor.authorZhu, Yuanming
dc.contributor.authorLoso, Michael R.
dc.contributor.authorWatson, Gerald B.
dc.contributor.authorSparks, Thomas C.
dc.contributor.authorRogers, Richard B.
dc.contributor.authorHuang, Jim X.
dc.contributor.authorGerwick, B. Clifford
dc.contributor.authorBabcock, Jonathan M.
dc.contributor.authorKelley, Donald
dc.contributor.authorHegde, Vidyadhar B.
dc.contributor.authorNugent, Benjamin M.
dc.contributor.authorRenga, James M.
dc.contributor.authorDenholm, Ian
dc.contributor.authorGorman, Kevin
dc.contributor.authorDeBoer, Gerrit J.
dc.contributor.authorHasler, James
dc.contributor.authorMeade, Thomas
dc.contributor.authorThomas, James D.
dc.date.accessioned2013-09-04T09:14:59Z
dc.date.available2013-09-04T09:14:59Z
dc.date.issued2011-04-13
dc.identifier.citationZhu , Y , Loso , M R , Watson , G B , Sparks , T C , Rogers , R B , Huang , J X , Gerwick , B C , Babcock , J M , Kelley , D , Hegde , V B , Nugent , B M , Renga , J M , Denholm , I , Gorman , K , DeBoer , G J , Hasler , J , Meade , T & Thomas , J D 2011 , ' Discovery and Characterization of Sulfoxaflor, a Novel Insecticide Targeting Sap-Feeding Pests ' , Journal of Agricultural and Food Chemistry , vol. 59 , no. 7 , pp. 2950-2957 . https://doi.org/10.1021/jf102765x
dc.identifier.issn0021-8561
dc.identifier.otherORCID: /0000-0001-9797-874X/work/35873692
dc.identifier.urihttp://hdl.handle.net/2299/11522
dc.description.abstractThe discovery of sulfoxaflor [N-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-lambda(4)-sulfanylidene] cyanamide] resulted from an investigation of the sulfoximine functional group as a novel bioactive scaffold for insecticidal activity and a subsequent extensive structure activity relationship study. Sulfoxaflor, the first product from this new class (the sulfoximines) of insect control agents, exhibits broad-spectrum efficacy against many sap-feeding insect pests, including aphids, whiteflies, hoppers, and Lygus, with levels of activity that are comparable to those of other classes of insecticides targeting sap-feeding insects, including the neonicotinoids. However, no cross-resistance has been observed between sulfoxaflor and neonicotinoids such as imidacloprid, apparently the result of differences in susceptibility to oxidative metabolism. Available data are consistent with sulfoxaflor acting via the insect nicotinic receptor in a complex manner. These observations reflect the unique structure of the sulfoximines compared with neonicotinoids.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofJournal of Agricultural and Food Chemistry
dc.subjectDROSOPHILA
dc.subjectNEONICOTINOID INSECTICIDES
dc.subjectSULFIDES
dc.subjectMYZUS-PERSICAE
dc.subjectNICOTINIC ACETYLCHOLINE-RECEPTORS
dc.subjectinsecticide resistance
dc.subjectsulfoximines
dc.subjectQ-BIOTYPE
dc.subjectHEMIPTERA APHIDIDAE
dc.subjectsulfoxaflor
dc.subjectRESISTANCE
dc.subjectEXPRESSION
dc.subjectMyzus persicae
dc.subjectBEMISIA-TABACI
dc.subjectnicotinic acetylcholine receptor
dc.titleDiscovery and Characterization of Sulfoxaflor, a Novel Insecticide Targeting Sap-Feeding Pestsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCrop Protection and Climate Change
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionCentre for Agriculture, Food and Environmental Management Research
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.1021/jf102765x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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