Show simple item record

dc.contributor.authorVafeiadou, Katerina
dc.contributor.authorWeech, Michelle
dc.contributor.authorSharma, Vandana
dc.contributor.authorYaqoob, Parveen
dc.contributor.authorTodd, Susan
dc.contributor.authorWilliams, Christine M.
dc.contributor.authorJackson, Kim G.
dc.contributor.authorLovegrove, Julie A.
dc.date.accessioned2013-09-05T09:00:05Z
dc.date.available2013-09-05T09:00:05Z
dc.date.issued2012-02
dc.identifier.citationVafeiadou , K , Weech , M , Sharma , V , Yaqoob , P , Todd , S , Williams , C M , Jackson , K G & Lovegrove , J A 2012 , ' A review of the evidence for the effects of total dietary fat, saturated, monounsaturated and n-6 polyunsaturated fatty acids on vascular function, endothelial progenitor cells and microparticles ' , British Journal of Nutrition , vol. 107 , no. 3 , pp. 303-24 . https://doi.org/10.1017/S0007114511004764
dc.identifier.issn0007-1145
dc.identifier.urihttp://hdl.handle.net/2299/11556
dc.description.abstractVascular dysfunction is recognised as an integrative marker of CVD. While dietary strategies aimed at reducing CVD risk include reductions in the intake of SFA, there are currently no clear guidelines on what should replace SFA. The purpose of this review was to assess the evidence for the effects of total dietary fat and individual fatty acids (SFA, MUFA and n-6 PUFA) on vascular function, cellular microparticles and endothelial progenitor cells. Medline was systematically searched from 1966 until November 2010. A total of fifty-nine peer-reviewed publications (covering fifty-six studies), which included five epidemiological, eighteen dietary intervention and thirty-three test meal studies, were identified. The findings from the epidemiological studies were inconclusive. The limited data available from dietary intervention studies suggested a beneficial effect of low-fat diets on vascular reactivity, which was strongest when the comparator diet was high in SFA, with a modest improvement in measures of vascular reactivity when high-fat, MUFA-rich diets were compared with SFA-rich diets. There was consistent evidence from the test meal studies that high-fat meals have a detrimental effect on postprandial vascular function. However, the evidence for the comparative effects of test meals rich in MUFA or n-6 PUFA with SFA on postprandial vascular function was limited and inconclusive. The lack of studies with comparable within-study dietary fatty acid targets, a variety of different study designs and different methods for determining vascular function all confound any clear conclusions on the impact of dietary fat and individual fatty acids on vascular function.en
dc.format.extent22
dc.format.extent201620
dc.language.isoeng
dc.relation.ispartofBritish Journal of Nutrition
dc.subjectCardiovascular Diseases
dc.subjectCell-Derived Microparticles
dc.subjectDiet, Fat-Restricted
dc.subjectDietary Fats
dc.subjectEndothelium, Vascular
dc.subjectEvidence-Based Medicine
dc.subjectFatty Acids, Monounsaturated
dc.subjectFatty Acids, Omega-6
dc.subjectHumans
dc.subjectStem Cells
dc.titleA review of the evidence for the effects of total dietary fat, saturated, monounsaturated and n-6 polyunsaturated fatty acids on vascular function, endothelial progenitor cells and microparticlesen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionFood Policy, Nutrition and Diet
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.1017/S0007114511004764
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record