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dc.contributor.authorIncani, Alessandra
dc.contributor.authorDeiana, Monica
dc.contributor.authorCorona, Giulia
dc.contributor.authorVafeiadou, Katerina
dc.contributor.authorVauzour, David
dc.contributor.authorDessì, M. Assunta
dc.contributor.authorSpencer, Jeremy P. E.
dc.identifier.citationIncani , A , Deiana , M , Corona , G , Vafeiadou , K , Vauzour , D , Dessì , M A & Spencer , J P E 2010 , ' Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol ' , Molecular Nutrition and Food Research , vol. 54 , no. 6 , pp. 788-96 .
dc.identifier.otherPURE: 2228349
dc.identifier.otherPURE UUID: 23cf9560-d53d-4356-9f4c-553c238c0440
dc.identifier.otherPubMed: 20024934
dc.identifier.otherScopus: 77954001205
dc.description.abstractThe olive oil polyphenol, hydroxytyrosol (HT), is believed to be capable of exerting protection against oxidative kidney injury. In this study we have investigated the ability of HT and its O-methylated metabolite, homovanillic alcohol (HVA) to protect renal cells against oxidative damage induced by hydrogen peroxide. We show that both compounds were capable of inhibiting hydrogen peroxide-induced kidney cell injury via an ability to interact with both MAP kinase and PI3 kinase signalling pathways, albeit at different concentrations. HT strongly inhibited death and prevented peroxide-induced increases in ERK1/2 and JNK1/2/3 phosphorylation at 0.3 microM, whilst HVA was effective at 10 microM. At similar concentrations, both compounds also prevented peroxide-induced reductions in Akt phosphorylation. We suggest that one potential protective effect exerted by olive oil polyphenols against oxidative kidney cell injury may be attributed to the interactions of HT and HVA with these important intracellular signalling pathways.en
dc.relation.ispartofMolecular Nutrition and Food Research
dc.subjectCell Survival
dc.subjectCells, Cultured
dc.subjectExtracellular Signal-Regulated MAP Kinases
dc.subjectHomovanillic Acid
dc.subjectHydrogen Peroxide
dc.subjectJNK Mitogen-Activated Protein Kinases
dc.subjectPhenylethyl Alcohol
dc.subjectProto-Oncogene Proteins c-akt
dc.subjectSignal Transduction
dc.titleInvolvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcoholen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionNutrition and Dietetics
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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