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dc.contributor.authorIravani, Mahmoud M.
dc.contributor.authorHaddon, C. O.
dc.contributor.authorRose, S.
dc.contributor.authorJenner, P.
dc.date.accessioned2013-09-16T14:30:16Z
dc.date.available2013-09-16T14:30:16Z
dc.date.issued2006-01-05
dc.identifier.citationIravani , M M , Haddon , C O , Rose , S & Jenner , P 2006 , ' 3-Nitrotyrosine-dependent dopaminergic neurotoxicity following direct nigral administration of a peroxynitrite but not a nitric oxide donor ' , Brain Research , vol. 1067 , no. 1 , pp. 256-262 . https://doi.org/10.1016/j.brainres.2005.10.086
dc.identifier.issn0006-8993
dc.identifier.otherPURE: 735323
dc.identifier.otherPURE UUID: fa72495d-769a-4c8b-acc4-abbc911b6665
dc.identifier.otherWOS: 000235356500031
dc.identifier.otherScopus: 31144444686
dc.identifier.otherORCID: /0000-0002-4905-9682/work/32997587
dc.identifier.urihttp://hdl.handle.net/2299/11568
dc.description.abstractThe presence of 3-nitrotyrosine (3-NT) adducts in Lewy bodies in Parkinson's disease suggests a role for nitrative stress in dopaminergic cell death. Whether this is a direct effect of increased nitric oxide (NO) formation or requires its reaction with superoxide to form peroxynitrite is not clear. In the present study, we show that direct nigral administration of a NO donor, SNOG, in the rat produced only local toxicity to dopaminergic neurones prelabeled with fluorogold with no 3-NT formation. However, administration of a peroxynitrite donor, SIN-1, caused widespread damage to dopaminergic neurones and marked expression of 3-NT immunoreactivity. Importantly, dopaminergic cell loss and the expression of 3-NT were completely prevented when SIN-1 was co-administered with the NO/peroxynitrite scavenger, carboxy-PTIO. The results suggest that increased NO formation is not inherently toxic to dopaminergic neurons, but when both oxidative and nitrative stress combine to cause peroxynitrite formation, neurotoxicity occurs. (c) 2005 Elsevier B.V. All rights reserved.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofBrain Research
dc.subjectsubstantia nigra
dc.subjectdopaminergic neurones
dc.subjectnitric oxide
dc.subjectperoxynitrite
dc.subject3-nitrotyrosine
dc.subjectParkinson's disease
dc.subjectPARKINSONS-DISEASE
dc.subjectOXIDATIVE STRESS
dc.subjectSUBSTANTIA-NIGRA
dc.subjectIN-VIVO
dc.subjectSYNTHASE PROTECTS
dc.subjectS-NITROSOTHIOLS
dc.subjectNEURODEGENERATION
dc.subjectINHIBITION
dc.subjectDEGENERATION
dc.subjectNEURONS
dc.title3-Nitrotyrosine-dependent dopaminergic neurotoxicity following direct nigral administration of a peroxynitrite but not a nitric oxide donoren
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.brainres.2005.10.086
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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