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        Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets

        Author
        Patel, Viral F.
        Patel, Natavarlal M.
        Attention
        2299/11572
        Abstract
        The present investigation explored the use of xanthan gum and guar gum for development of floating drug delivery system of dipyridamole using factorial design approach. The content of polymer blends (X(1)) and ratio of xanthan gum to guar gum (X(2)) were selected as independent variables. The diffusion exponent (n), release rate constant (k), percentage drug release at 1 hr (Q(1)) and 6 hr (Q(6)) were selected as dependent variables. Tablets of all batches had desired buoyancy characteristics. Multiple regression analysis with two way ANOVA revealed that both the factors had statistically significant influence on the response studied (p
        Publication date
        2007
        Published in
        Drug Development and Industrial Pharmacy
        Published version
        https://doi.org/10.1080/03639040601050155
        Other links
        http://hdl.handle.net/2299/11572
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