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        The phagocytic capacity of neurones

        Author
        Bowen, Samantha
        Ateh, Davidson D.
        Deinhardt, Katrin
        Bird, Margaret M.
        Price, Karen M.
        Baker, Cathy S.
        Robson, Joanna C.
        Swash, Michael
        Shamsuddin, Wassim
        Kawar, Shalini
        El-Tawil, Tariq
        Roos, Jesper
        Hoyle, Andrew
        Nickols, Carole D.
        Knowles, Charles H.
        Pullen, Anthony H.
        Luthert, Phillip J.
        Weller, Roy O.
        Hafezparast, Majid
        Franklin, Robin J. M.
        Revesz, Tamas
        King, Rosalind H. M.
        Berninghausen, Otto
        Fisher, Elizabeth M. C.
        Schiavo, Giampietro
        Martin, Joanne E.
        Attention
        2299/11581
        Abstract
        Phagocytosis is defined as the ingestion of particulates over 0.5 microm in diameter and is associated with cells of the immune system such as macrophages or monocytes. Neurones are not generally recognized to be phagocytic. Using light, confocal, time-lapse and electron microscopy, we carried out a wide range of in-vitro and in-vivo experiments to examine the phagocytic capacity of different neuronal cell types. We demonstrated phagocytosis of material by neurones, including cell debris and synthetic particles up to 2.8 microm in diameter. We showed phagocytosis in different neuronal types, and demonstrated that debris can be transported from neurite extremities to cell bodies and persist within neurones. Flow cytometry analysis demonstrated the lack of certain complement receptors on neurones but the presence of others, including integrin receptors known to mediate macrophage phagocytosis, indicating that a restricted set of phagocytosis receptors may mediate this process. Neuronal phagocytosis occurs in vitro and in vivo, and we propose that this is a more widespread and significant process than previously recognized. Neuronal phagocytosis may explain certain inclusions in neurones during disease, cell-to-cell spread of disease, neuronal death during disease progression and provide a potential mechanism for therapeutic intervention through the delivery of particulate drug carriers.
        Publication date
        2007-05
        Published in
        European Journal of Neuroscience
        Published version
        https://doi.org/10.1111/j.1460-9568.2007.05554.x
        Other links
        http://hdl.handle.net/2299/11581
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