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        Mechanistic studies leading to a new procedure for rapid microwave assisted generation of pyridine-3,5-dicarbonitrile libraries

        Author
        Guo, Kai
        Thompson, Mark J.
        Reddy, Tummala Rama Krishna
        Mutter , Roger
        Chen, Beining
        Attention
        2299/11596
        Abstract
        Mechanistic investigations into the multi-component synthesis of pyridine-3,5-dicarbonitriles have established a defined reaction pathway, particularly clarifying the role of aerobic oxidation in conversion of the intermediate 1,4-dihydropyridines into the final products. Based on such improved understanding of the reaction mechanism, optimised conditions for the preparation of compound libraries based on this core structure have been developed and represent a significant improvement in yield over existing protocols. Particularly, microwave assisted synthesis was found to provide a procedure suitable for high-throughput synthesis of pyridine-3,5-dicarbonitrile libraries.
        Publication date
        2007-06-11
        Published in
        Tetrahedron
        Published version
        https://doi.org/10.1016/j.tet.2007.03.139
        Other links
        http://hdl.handle.net/2299/11596
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