Show simple item record

dc.contributor.authorZloh, Mire
dc.contributor.authorBucar, F.
dc.contributor.authorGibbons, S.
dc.identifier.citationZloh , M , Bucar , F & Gibbons , S 2007 , ' Quantum chemical studies on structure activity relationship of natural product polyacetylenes ' , Theoretical Chemistry Accounts , vol. 117 , no. 2 , pp. 247-252 .
dc.identifier.otherPURE: 1447805
dc.identifier.otherPURE UUID: 89e0d410-f4a3-43db-b6a2-912626da1770
dc.identifier.otherScopus: 33846594197
dc.descriptionCopyright 2007 Elsevier B.V., All rights reserved.
dc.description.abstractAn extract of the roots of Levisticum officinale L. (Apiaceae) exhibited significant antimycobacterial activity against Mycobacterium fortuitum, where diacetylene compounds were identified as the active components in this extract. In contrast, polyacetylenes isolated from different sources surprisingly exhibited no anti-mycobacterial activity. Additionally, a whole series of furanocoumarin ethers of the polyacetylene falcarindiol exhibited anti-proliferative properties. We have studied the relationship between the electronic properties and biological activity of these structurally related compounds and a good qualitative correlation between predicted lipophilic parameters and activity has been established.en
dc.relation.ispartofTheoretical Chemistry Accounts
dc.titleQuantum chemical studies on structure activity relationship of natural product polyacetylenesen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record