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        Neurabin-I is phosphorylated by Cdk5 : Implications for neuronal morphogenesis and cortical migration

        Author
        Causeret, F.
        Jacobs, T.
        Terao, M.
        Heath, O.
        Hoshino, M.
        Nikolic, Margareta
        Attention
        2299/11605
        Abstract
        The correct morphology and migration of neurons, which is essential for the normal development of the nervous system, is enabled by the regulation of their cytoskeletal elements. We reveal that Neurabin-I, a neuronal-specific F-actin-binding protein, has an essential function in the developing forebrain. We show that gain and loss of Neurabin-I expression affect neuronal morphology, neurite outgrowth, and radial migration of differentiating cortical and hippocampal neurons, suggesting that tight regulation of Neurabin-I function is required for normal forebrain development. Importantly, loss of Neurabin-I prevents pyramidal neurons from migrating into the cerebral cortex, indicating its essential role during early stages of corticogenesis. We demonstrate that in neurons Rac1 activation is affected by the expression levels of Neurabin-I. Furthermore, the Cdk5 kinase, a key regulator of neuronal migration and morphology, directly phosphorylates Neurabin-I and controls its association with F-actin. Mutation of the Cdk5 phosphorylation site reduces the phenotypic consequences of Neurabin-I overexpression both in vitro and in vivo, suggesting that Neurabin-I function depends, at least in part, on its phosphorylation status. Together our findings provide new insight into the signaling pathways responsible for controlled changes of the F-actin cytoskeleton that are required for normal development of the forebrain.
        Publication date
        2007-11-01
        Published in
        Molecular Biology of the Cell
        Published version
        https://doi.org/10.1091/mbc.E07-04-0372
        Other links
        http://hdl.handle.net/2299/11605
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