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dc.contributor.authorHarrington, L.S.
dc.contributor.authorBelcher, E.
dc.contributor.authorMoreno, L.
dc.contributor.authorMitchell, J.A.
dc.contributor.authorCarrier, M.J.
dc.identifier.citationHarrington , L S , Belcher , E , Moreno , L , Mitchell , J A & Carrier , M J 2007 , ' Homeostatic role of toll-like receptor 4 in the endothelium and heart ' , Journal of Cardiovascular Pharmacology and Therapeutics , vol. 12 , no. 4 , pp. 322-326 .
dc.identifier.otherPURE: 1744827
dc.identifier.otherPURE UUID: ca175782-6cfc-418d-b9a7-eb1df38e8743
dc.identifier.otherScopus: 37249027870
dc.descriptionMEDLINE® is the source for the MeSH terms of this document.
dc.description.abstractToll-like receptor 4 (TLR4) is a pattern recognition receptor for lipopolysaccharide from Gram negative bacteria and thus is integral to the innate immune response in mammals. In addition, TLR4 is associated with atherosclerosis in murine models. The current study shows that blood vessels from TLR4-/- mice have an intact endothelial layer and comparable expression of nitric oxide synthase 3 protein. However, endothelium-dependent dilation in response to acetylcholine in vessels from TLR4-/- mice is greatly reduced. By contrast, endothelium-independent smooth muscle dilation in response to sodium nitroprusside in vessels from TLR4-/- mice remains intact. Furthermore, this study shows that hearts from TLR4-/- mice display signs of left ventricular dilation. In contrast to results in vessels from TLR4-/- mice, endothelium-dependent responses to acetylcholine in vessels from TLR2-/- mice remain intact. These observations illustrate a novel role for TLR4 in the homeostatic control of a functional endothelium and, thereby, cardiovascular health.en
dc.relation.ispartofJournal of Cardiovascular Pharmacology and Therapeutics
dc.titleHomeostatic role of toll-like receptor 4 in the endothelium and hearten
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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