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dc.contributor.authorVauzour, David
dc.contributor.authorVafeiadou, Katerina
dc.contributor.authorSpencer, Jeremy P. E.
dc.identifier.citationVauzour , D , Vafeiadou , K & Spencer , J P E 2007 , ' Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols ' , Biochemical and Biophysical Research Communications , vol. 362 , no. 2 , pp. 340-6 .
dc.description.abstractThe death of nigral neurons in Parkinson's disease is thought to involve the formation of the endogenous neurotoxin, 5-S-cysteinyl-dopamine. In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine via their capacity to undergo tyrosinase-induced oxidation to yield cysteinyl-polyphenol adducts. In contrast, the inhibition afforded by the flavanone, hesperetin, was not accompanied by the formation of cysteinyl-hesperetin adducts, indicating that it may inhibit via direct interaction with tyrosinase. Whilst the stilbene resveratrol also inhibited 5-S-cysteinyl-dopamine formation, this was accompanied by the formation of dihydrobenzothiazine, a strong neurotoxin. Our data indicate that the inhibitory effects of polyphenols against 5-S-cysteinyl-dopamine formation are structure-dependent and shed further light on the mechanisms by which polyphenols exert protection against neuronal injury relevant to neurodegenerative diseases.en
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.subjectChromatography, High Pressure Liquid
dc.subjectMass Spectrometry
dc.subjectMonophenol Monooxygenase
dc.titleInhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenolsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionFood Policy, Nutrition and Diet
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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