Show simple item record

dc.contributor.authorVauzour, David
dc.contributor.authorVafeiadou, Katerina
dc.contributor.authorSpencer, Jeremy P. E.
dc.date.accessioned2013-09-17T11:00:19Z
dc.date.available2013-09-17T11:00:19Z
dc.date.issued2007-10-19
dc.identifier.citationVauzour , D , Vafeiadou , K & Spencer , J P E 2007 , ' Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols ' , Biochemical and Biophysical Research Communications , vol. 362 , no. 2 , pp. 340-6 . https://doi.org/10.1016/j.bbrc.2007.07.153
dc.identifier.issn0006-291X
dc.identifier.otherPURE: 2234369
dc.identifier.otherPURE UUID: 6fc6d42c-adf5-4d31-ab54-c5bb9de79ac6
dc.identifier.otherPubMed: 17716620
dc.identifier.otherScopus: 34548250927
dc.identifier.urihttp://hdl.handle.net/2299/11613
dc.description.abstractThe death of nigral neurons in Parkinson's disease is thought to involve the formation of the endogenous neurotoxin, 5-S-cysteinyl-dopamine. In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine via their capacity to undergo tyrosinase-induced oxidation to yield cysteinyl-polyphenol adducts. In contrast, the inhibition afforded by the flavanone, hesperetin, was not accompanied by the formation of cysteinyl-hesperetin adducts, indicating that it may inhibit via direct interaction with tyrosinase. Whilst the stilbene resveratrol also inhibited 5-S-cysteinyl-dopamine formation, this was accompanied by the formation of dihydrobenzothiazine, a strong neurotoxin. Our data indicate that the inhibitory effects of polyphenols against 5-S-cysteinyl-dopamine formation are structure-dependent and shed further light on the mechanisms by which polyphenols exert protection against neuronal injury relevant to neurodegenerative diseases.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.subjectChromatography, High Pressure Liquid
dc.subjectDopamine
dc.subjectFlavonoids
dc.subjectMass Spectrometry
dc.subjectMonophenol Monooxygenase
dc.subjectNeurotoxins
dc.subjectPhenols
dc.subjectPolyphenols
dc.titleInhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenolsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionNutrition and Dietetics
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.bbrc.2007.07.153
rioxxterms.typeJournal Article/Review


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record