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        Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women

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        906532.pdf (PDF, 254Kb)
        Author
        Weickert, Martin O.
        Reimann, Manja
        Otto, Bärbel
        Hall, Wendy L.
        Vafeiadou, Katerina
        Hallund, Jesper
        Ferrari, Marika
        Talbot, Duncan
        Branca, Francesco
        Bügel, Susanne
        Williams, Christine M
        Zunft, Hans-Joachim
        Koebnick, Corinna
        Attention
        2299/11777
        Abstract
        Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) and ghrelin, and thus influence body weight. In a randomized, double-blind, placebo-controlled, cross-over trial with 34 healthy postmenopausal women (59 +/- 6 years, BMI: 24.7 +/- 2.8 kg/m2), isoflavone-enriched cereal bars (50 mg isoflavones/day; genistein to daidzein ratio 2:1) or non-isoflavone-enriched control bars were consumed for 8 weeks (wash-out period: 8-weeks). Seventeen of the subjects were classified as equol producers. Plasma concentrations of ghrelin and PYY, as well as energy intake and body weight were measured at baseline and after four and eight weeks of each intervention arm.
        Publication date
        2006
        Published in
        Journal of Negative Results in BioMedicine
        Published version
        https://doi.org/10.1186/1477-5751-5-11
        Other links
        http://hdl.handle.net/2299/11777
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