Evidence for associations between common polymorphisms of estrogen receptor beta gene with homocysteine and nitric oxide

Reimann, M.; Vafeiadou, K.; Hall, W. L.; Dierkes, J.; Nilsson, M.; Dahlman-Wright, K.; Ferrari, M.; Huebner, U.; Hallund, J.; Bugel, S.; Branca, F.; Williams, C. M.; Koebnick, C.

Author

Reimann, M.

Vafeiadou, K.

Hall, W. L.

Dierkes, J.

Nilsson, M.

Dahlman-Wright, K.

Ferrari, M.

Huebner, U.

Hallund, J.

Bugel, S.

Branca, F.

Williams, C. M.

Koebnick, C.

Abstract

Homocysteine and asymmetric dimethylarginine (ADMA) affect nitric oxide (NO) concentration, thereby contributing to cardiovascular disease (CVD). Both amino acids can be reduced in vivo by estrogen. Variation in the estrogen receptor (ER) may influence homocysteine and ADMA, yet no information is available on associations with single nucleotide polymorphisms in the estrogen receptor genes ERalpha (PvuII and XbaI) and ERbeta (1730G-->A and cx + 56 G-->A).