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dc.contributor.authorPollard, Susan E.
dc.contributor.authorKuhnle, Gunter G. C.
dc.contributor.authorVauzour, David
dc.contributor.authorVafeiadou, Katerina
dc.contributor.authorTzounis, Xenofon
dc.contributor.authorWhiteman, Matthew
dc.contributor.authorRice-Evans, Catherine
dc.contributor.authorSpencer, Jeremy P. E.
dc.identifier.citationPollard , S E , Kuhnle , G G C , Vauzour , D , Vafeiadou , K , Tzounis , X , Whiteman , M , Rice-Evans , C & Spencer , J P E 2006 , ' The reaction of flavonoid metabolites with peroxynitrite ' , Biochemical and Biophysical Research Communications , vol. 350 , no. 4 , pp. 960-8 .
dc.description.abstractThere is much interest in the bioactivity of in vivo flavonoid metabolites. We report for the first time the hierarchy of reactivity of flavonoid metabolites with peroxynitrite and characterise novel reaction products. O-Methylation of the B-ring catechol containing flavonoids epicatechin and quercetin, and O-glucuronidation of all flavonoids reduced their reactivity with peroxynitrite. The reaction of the flavanones hesperetin and naringenin and their glucuronides resulted in the formation of multiple mono-nitrated and nitrosated products. In contrast, the catechol-containing flavonoids epicatechin and quercetin yielded oxidation products which when trapped with glutathione led to the production of glutathionyl-conjugates. However, the O-methylated metabolites of epicatechin yielded both mono- and di-nitrated products and nitrosated metabolites. The 3'-O-methyl metabolite of quercetin also yielded a nitrosated species, although its counterpart 4'-O-methyl quercetin yielded only oxidation products. Such products may represent novel metabolic products in vivo and may also express cellular activity.en
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.subjectPeroxynitrous Acid
dc.titleThe reaction of flavonoid metabolites with peroxynitriteen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionFood Policy, Nutrition and Diet
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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