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dc.contributor.authorBhatti, Muhammad F.
dc.contributor.authorJamal, Atif
dc.contributor.authorPetrou, Michael A.
dc.contributor.authorCairns, Timothy C.
dc.contributor.authorBignell, Elaine M.
dc.contributor.authorCoutts, Robert H.A.
dc.date.accessioned2013-10-16T20:18:24Z
dc.date.available2013-10-16T20:18:24Z
dc.date.issued2011-11
dc.identifier.citationBhatti , M F , Jamal , A , Petrou , M A , Cairns , T C , Bignell , E M & Coutts , R H A 2011 , ' The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus ' , Fungal Genetics and Biology , vol. 48 , no. 11 , pp. 1071-5 . https://doi.org/10.1016/j.fgb.2011.07.008
dc.identifier.issn1096-0937
dc.identifier.otherPURE: 1908908
dc.identifier.otherPURE UUID: ac4b8fb5-29a0-496d-bc16-8c7750a8de74
dc.identifier.otherPubMed: 21840413
dc.identifier.otherScopus: 80053273582
dc.identifier.urihttp://hdl.handle.net/2299/11782
dc.description.abstractSome isolates of the opportunistic human pathogenic fungus Aspergillus fumigatus are known to be infected with mycoviruses. The dsRNA genomes of two of these mycoviruses, which include a chrysovirus and a partitivirus, have been completely sequenced and an RT-PCR assay for the viruses has been developed. Through curing virus-infected A. fumigatus isolates by cycloheximide treatment and transfecting virus-free isolates with purified virus, as checked by RT-PCR, isogenic virus-free and virus-infected lines of the fungus were generated whose phenotypes and growth have been directly compared. Mycovirus infection of A. fumigatus with either the chrysovirus or the partitivirus resulted in significant aberrant phenotypic alterations and attenuation of growth of the fungus but had no effect on susceptibility to common antifungals. Chrysovirus infection of A. fumigatus caused no significant alterations to murine pathogenicity.en
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofFungal Genetics and Biology
dc.subjectVirulence
dc.subjectAnimals
dc.subjectLung
dc.subjectRNA Viruses
dc.subjectAspergillus fumigatus
dc.subjectDisease Models, Animal
dc.subjectColony Count, Microbial
dc.subjectMice
dc.subjectAspergillosis
dc.titleThe effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatusen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionGeography, Environment and Agriculture
dc.contributor.institutionCrop and Environmental Protection
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.fgb.2011.07.008
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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