dc.contributor.author | Heidelberger, Sibylle | |
dc.contributor.author | Zinzalla, Giovanna | |
dc.contributor.author | Antonow, Dyeison | |
dc.contributor.author | Essex, Samantha | |
dc.contributor.author | Piku Basu, B. | |
dc.contributor.author | Palmer, Jonathan | |
dc.contributor.author | Husby, Jarmila | |
dc.contributor.author | Jackson, Paul J. M. | |
dc.contributor.author | Rahman, Khondaker M. | |
dc.contributor.author | Wilderspin, Andrew F. | |
dc.contributor.author | Zloh, Mire | |
dc.contributor.author | Thurston, David E. | |
dc.date.accessioned | 2013-10-17T10:00:50Z | |
dc.date.available | 2013-10-17T10:00:50Z | |
dc.date.issued | 2013-08-15 | |
dc.identifier.citation | Heidelberger , S , Zinzalla , G , Antonow , D , Essex , S , Piku Basu , B , Palmer , J , Husby , J , Jackson , P J M , Rahman , K M , Wilderspin , A F , Zloh , M & Thurston , D E 2013 , ' Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry ' , Bioorganic and Medicinal Chemistry Letters , vol. 23 , no. 16 , pp. 4719-4722 . https://doi.org/10.1016/j.bmcl.2013.05.066 | |
dc.identifier.issn | 0960-894X | |
dc.identifier.other | PURE: 2092443 | |
dc.identifier.other | PURE UUID: 873b3cc2-c622-4dc7-b663-4ff964bd3b63 | |
dc.identifier.other | PubMed: 23810499 | |
dc.identifier.other | Scopus: 84880577437 | |
dc.identifier.uri | http://hdl.handle.net/2299/11798 | |
dc.description.abstract | STAT3 (Signal Transducer and Activator of Transcription factor 3) is constitutively active in a wide range of human tumours. Stattic is one of the first non-peptidic small molecules reported to inhibit formation of the STAT3:STAT3 protein dimer complex. A mass spectrometry method has been developed to investigate the binding of Stattic to the un-phosphorylated STAT3βtc (U-STAT3) protein. Alkylation of four cysteine residues has been observed with possible reaction at a fifth which could account for the mechanism of action. | en |
dc.language.iso | eng | |
dc.relation.ispartof | Bioorganic and Medicinal Chemistry Letters | |
dc.title | Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry | en |
dc.contributor.institution | Department of Pharmacy | |
dc.contributor.institution | Medicinal and Analytical Chemistry | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | https://doi.org/10.1016/j.bmcl.2013.05.066 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |