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Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry

dc.contributor.authorHeidelberger, Sibylle
dc.contributor.authorZinzalla, Giovanna
dc.contributor.authorAntonow, Dyeison
dc.contributor.authorEssex, Samantha
dc.contributor.authorPiku Basu, B.
dc.contributor.authorPalmer, Jonathan
dc.contributor.authorHusby, Jarmila
dc.contributor.authorJackson, Paul J. M.
dc.contributor.authorRahman, Khondaker M.
dc.contributor.authorWilderspin, Andrew F.
dc.contributor.authorZloh, Mire
dc.contributor.authorThurston, David E.
dc.date.accessioned2013-10-17T10:00:50Z
dc.date.available2013-10-17T10:00:50Z
dc.date.issued2013-08-15
dc.identifier.citationHeidelberger , S , Zinzalla , G , Antonow , D , Essex , S , Piku Basu , B , Palmer , J , Husby , J , Jackson , P J M , Rahman , K M , Wilderspin , A F , Zloh , M & Thurston , D E 2013 , ' Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry ' , Bioorganic and Medicinal Chemistry Letters , vol. 23 , no. 16 , pp. 4719-4722 . https://doi.org/10.1016/j.bmcl.2013.05.066
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/2299/11798
dc.description.abstractSTAT3 (Signal Transducer and Activator of Transcription factor 3) is constitutively active in a wide range of human tumours. Stattic is one of the first non-peptidic small molecules reported to inhibit formation of the STAT3:STAT3 protein dimer complex. A mass spectrometry method has been developed to investigate the binding of Stattic to the un-phosphorylated STAT3βtc (U-STAT3) protein. Alkylation of four cysteine residues has been observed with possible reaction at a fifth which could account for the mechanism of action.en
dc.language.isoeng
dc.relation.ispartofBioorganic and Medicinal Chemistry Letters
dc.titleInvestigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometryen
dc.contributor.institutionPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.1016/j.bmcl.2013.05.066
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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