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        Patent: Preparation of pyrrole derivatives as S100 protein binding interaction inhibitors for the treatment of cancer and other diseases

        Author
        Department of Pharmacy
        School of Life and Medical Sciences
        Health & Human Sciences Research Institute
        Medicinal and Analytical Chemistry
        Reddy, Tummala Rama Krishna
        Li, Chan
        Fischer, Peter M.
        Dekker, Lodewijk V.
        Attention
        2299/12090
        Abstract
        This invention relates to compounds that are inhibitors of S100 protein binding interactions, such as, for example, the annexin A2-S100A10 protein binding interaction. More specifically, this invention concerns certain substituted pyrrole derivatives of the general formula I or II as defined in patent, as well as processes for preparing these derivatives, pharmaceutical compositions comprising these derivatives and their use in the treatment, prevention or delay of progression of diseases in which S100 protein binding interactions are implicated (such as cancer).
        Publication date
        2011-08-04
        Other links
        http://hdl.handle.net/2299/12090
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