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        Peptide pills for brain diseases? : Reality and future perspectives

        Author
        Serrano Lopez, Dolores Remedios
        Lalatsa, Aikaterini
        Attention
        2299/12119
        Abstract
        The peptide therapeutic market is one of the fastest growth areas of the pharmaceutical industry. Although few orally administered peptides are marketed and many are in different phases of clinical development, there is no marketed oral peptide therapeutic used for CNS disorders. The major challenges involved in orally delivering peptides to the brain relate to their enzymatic instability and inability to permeate across physiological barriers. The paucity of therapies for the treatment of brain diseases and the presence of the blood-brain barrier excluding 98% of therapeutic molecules necessitates parenteral administration. Various approaches have been applied to enhance oral peptide bioavailability, but only nanoparticulate strategies were able to deliver orally therapeutic peptides to the brain. Although industry may be reluctant to invest in developing oral peptide nanomedicines, the increasingly unmet clinical need and economic burden associated with brain diseases will fuel the development of the first marketed oral-to-brain peptide therapy.
        Publication date
        2013-04
        Published in
        Therapeutic Delivery
        Published version
        https://doi.org/10.4155/tde.13.5
        Other links
        http://hdl.handle.net/2299/12119
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