Show simple item record

dc.contributor.authorShan, Dehong
dc.contributor.authorXie, Yongling
dc.contributor.authorRen, Guogang
dc.contributor.authorYang, Zhuo
dc.date.accessioned2013-11-13T12:31:04Z
dc.date.available2013-11-13T12:31:04Z
dc.date.issued2013-02
dc.identifier.citationShan , D , Xie , Y , Ren , G & Yang , Z 2013 , ' Attenuated effect of tungsten carbide nanoparticles on voltage-gated sodium current of hippocampal CA1 pyramidal neurons ' , Toxicology in Vitro , vol. 27 , no. 1 , pp. 299-304 . https://doi.org/10.1016/j.tiv.2012.08.025
dc.identifier.issn0887-2333
dc.identifier.otherPURE: 1972949
dc.identifier.otherPURE UUID: 805276a5-0b8b-4cc5-b4ec-e23bddcc267a
dc.identifier.otherPubMed: 22954532
dc.identifier.otherWOS: 000314371600035
dc.identifier.otherScopus: 85027935518
dc.identifier.otherORCID: /0000-0001-8865-1526/work/32373258
dc.identifier.urihttp://hdl.handle.net/2299/12120
dc.description.abstractNanomaterials and relevant products are now being widely used in the world, and their safety becomes a great concern for the general public. Tungsten carbide nanoparticles (nano-WC) are widely used in metallurgy, aeronautics and astronautics, however our knowledge regarding the influence of nano-WC on neurons is still lacking. The aim of this study was to investigate the impact of nano-WC on tetrodotoxin (TTX)-sensitive voltage-activated sodium current (I(Na)) of hippocampal CA1 pyramidal neurons. Results showed that acute exposure of nano-WC attenuated the peak amplitudes of I(Na) in a concentration-dependent manner. The minimal effective concentration was 10(-5)g/ml. The exposure of nano-WC significantly decreased current amplitudes of the current-voltage curves of I(Na) from -50 to+50 mV, shifted the steady-state activation and inactivation curves of I(Na) negatively and delayed the recovery of I(Na) from inactivation state. After exposure to nano-WC, the peak amplitudes, overshoots and the V-thresholds of action potentials (APs) were markedly reduced. These results suggested that exposure of nano-WC could influence some characteristics of APs evoked from the hippocampal CA1 neurons by modifying the kinetics of voltage-gated sodium channels (VGSCs).en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofToxicology in Vitro
dc.subjectTungsten carbide nanoparticles
dc.subjectHippocampus
dc.subjectVoltage-gated sodium current
dc.subjectAction potential
dc.subjectNeurotoxicity
dc.subjectMOLECULAR-MECHANISMS
dc.subjectULTRAFINE PARTICLES
dc.subjectCARBON-NANOTUBES
dc.subjectCHANNELS
dc.subjectTOXICITY
dc.subjectEXPOSURE
dc.subjectOXIDE
dc.subjectTRANSLOCATION
dc.subjectINACTIVATION
dc.subjectINSTILLATION
dc.titleAttenuated effect of tungsten carbide nanoparticles on voltage-gated sodium current of hippocampal CA1 pyramidal neuronsen
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionScience & Technology Research Institute
dc.contributor.institutionMaterials and Structures
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.tiv.2012.08.025
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record