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dc.contributor.authorPinto, T.M.
dc.contributor.authorSchilstra, M.
dc.contributor.authorSteuber, Volker
dc.date.accessioned2013-11-25T11:59:50Z
dc.date.available2013-11-25T11:59:50Z
dc.date.issued2012
dc.identifier.citationPinto , T M , Schilstra , M & Steuber , V 2012 , The effective calcium/calmodulin concentration determines the sensitivity of CaMKII to the frequency of calcium oscillations . in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) . vol. 7223 LNCS , pp. 131-135 . https://doi.org/10.1007/978-3-642-28792-3_17
dc.identifier.isbn978-3-642-28791-6
dc.identifier.isbn978-3-642-28792-3
dc.identifier.otherPURE: 1005929
dc.identifier.otherPURE UUID: 499c2ec4-b42b-4cbd-af21-183b805200ca
dc.identifier.otherScopus: 84859114410
dc.identifier.urihttp://hdl.handle.net/2299/12175
dc.description.abstractCalcium/calmodulin-dependent protein kinase II (CaMKII) is involved in the induction of many forms of synaptic plasticity in the brain. Experimental and computational studies have shown that CaMKII is sensitive to the frequency of oscillatory Ca signals. Here we demonstrate that in a simple, commonly used kinetic model of CaMKII phosphorylation, the overall phosphorylation rate under sustained application of Ca ∈- ∈CaM pulses ultimately depends on the average ('effective') concentration of Ca ∈-∈CaM in the system, rather than on the pulse frequency itself. As a corollary, equal phosphorylation levels are achieved in response to pulsed and constant applications of equal effective concentrations of Ca ∈-∈CaM.en
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
dc.titleThe effective calcium/calmodulin concentration determines the sensitivity of CaMKII to the frequency of calcium oscillationsen
dc.contributor.institutionSchool of Computer Science
dc.contributor.institutionScience & Technology Research Institute
dc.contributor.institutionCentre for Computer Science and Informatics Research
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84859114410&partnerID=8YFLogxK
dc.relation.schoolSchool of Computer Science
dcterms.dateAccepted2012
rioxxterms.versionofrecordhttps://doi.org/10.1007/978-3-642-28792-3_17
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue


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