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dc.contributor.authorPatel, Viralkumar
dc.contributor.authorPatel, Sunil
dc.date.accessioned2013-11-28T11:29:53Z
dc.date.available2013-11-28T11:29:53Z
dc.date.issued2013
dc.identifier.citationPatel , V & Patel , S 2013 , ' Delivering drug‑polymer complex via quick dissolving film : A step towards the development of an appropriate pediatric formulation ' , Asian Journal of Pharmaceutics , vol. 7 , no. 1 , pp. 21-26 . https://doi.org/10.4103/0973-8398.110932
dc.identifier.issn0973-8398
dc.identifier.otherPURE: 2528397
dc.identifier.otherPURE UUID: f7124032-9e08-483a-be0d-54e832074d83
dc.identifier.otherScopus: 84877107181
dc.identifier.urihttp://hdl.handle.net/2299/12222
dc.description.abstractLack of suitable prednisolone formulations for treatment of asthma could limit treatment compliance in pediatric population and hence the aim of this study was to develop prednisolone‑polymer complexes with enhanced solubility and to incorporate this complex into orally disintegrating films to enable rapid drug delivery. The prednisolone‑polymeric complexes were prepared using solvent evaporation and freeze drying techniques with a drug‑polymer ratio of 1:1 using hydroxypropyl β‑cyclodextrin (HP β‑CD), hydroxypropyl methylcellulose 4 cps, and polyvinylpyrrolidone K-30 as polymeric carriers and the parameters such as an aqueous solubility, dissolution profile, and solid‑state characterization using differential scanning calorimetry (DSC) of the complexes determined. The optimized complex was then incorporated into films prepared using solvent casting technique and the weight variation, thickness, solid‑state characterization, in vitro disintegration and dissolution profiles of the films were then determined. The highest prednisolone solubility was seen with the prednisolone‑HP β‑CD complex prepared by freeze drying (1.82 mg/mL) followed by the same complex prepared by solvent evaporation (1.70 mg/mL). The solubility’s were significantly higher compared to prednisolone powder (0.2 mg/mL) (P < 0.05). DSC analysis of complexes revealed a reduction in area of the endothermic peak indicating the presence of amorphous drug while in comparison, the DSC analysis of films did not show endothermic peak showing complete absence of crystalline drug. The fil was thin, uniform in weight and thickness, showing rapid disintegration of 55 s with almost complete drug release within 3 min. The study revealed the incorporated drug‑polymer complex have maintained the amorphous state and enabled rapid drug release.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofAsian Journal of Pharmaceutics
dc.subjectFreeze drying
dc.subjectpediatric drug delivery
dc.subjectprednisolone
dc.subjectquick dissolving thin film
dc.subjectsolid dispersions
dc.subjectsolvent evaporation
dc.titleDelivering drug‑polymer complex via quick dissolving film : A step towards the development of an appropriate pediatric formulationen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionPharmaceutics
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.4103/0973-8398.110932
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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