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dc.contributor.authorHou, Qingpu
dc.contributor.authorChau, David Y.S.
dc.contributor.authorPratoomsoot, Chayanin
dc.contributor.authorTighe, Patrick J.
dc.contributor.authorDua, Harminder S.
dc.contributor.authorShakesheff, Kevin M.
dc.contributor.authorRose, Felicity R. A. J.
dc.date.accessioned2013-12-03T15:30:00Z
dc.date.available2013-12-03T15:30:00Z
dc.date.issued2008-09
dc.identifier.citationHou , Q , Chau , D Y S , Pratoomsoot , C , Tighe , P J , Dua , H S , Shakesheff , K M & Rose , F R A J 2008 , ' In situ gelling hydrogels incorporating microparticles as drug delivery carriers for regenerative medicine ' , Journal of Pharmaceutical Sciences , vol. 97 , no. 9 , pp. 3972-3980 . https://doi.org/10.1002/jps.21310
dc.identifier.issn0022-3549
dc.identifier.otherPURE: 2585942
dc.identifier.otherPURE UUID: 55db9c4b-2f4b-45a5-9b94-ae627b9dd3ef
dc.identifier.otherWOS: 000258937100029
dc.identifier.otherScopus: 53549133106
dc.identifier.urihttp://hdl.handle.net/2299/12254
dc.description.abstractAqueous solutions of blends of biodegradable triblock copolymers, composed of poly(DL-lactide-co-glycolide) (PLGA) and poly(ethylene glycol) (PEG) with varied D,L-lactide to glycolide ratios, displayed thermosensitivity and formed a gel at body temperature. The gel window of the blend solutions could be tuned by varying the blending ratio between the two components. Furthermore, the storage modulus of the resultant hydrogel from the copolymer blends at body temperature was higher than that of each individual component. Incorporation of poly(D,L-lactide) (PDLLA) microparticles (0-5-40% w/v) within the in situ gelling hydrogel did not change the sol-gel transition temperatures of the polymer solutions, while the mechanical strength of the resultant hydrogels was enhanced when the content of the microparticles was increased up to 30% and 40%. Incorporation of proteins into both the gel and microparticle components resulted in composites that controlled the kinetics of protein release. Protein within the gel phase was released over a 10-day period whilst protein in the microparticles was released over a period of months. This system can be used to deliver two drugs with differing release kinetics and could be used to orchestrate tissue regeneration responses over differing timescales. (C) 2008 Wiley-Liss, Inc. and the American Pharmacists Association.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofJournal of Pharmaceutical Sciences
dc.subjectthermosensitive hydrogels
dc.subjectbiodegradable polymers
dc.subjectdrug delivery carriers
dc.subjectpolymer microparticles
dc.subjectINJECTABLE THERMOSENSITIVE HYDROGEL
dc.subjectBIODEGRADABLE BLOCK-COPOLYMERS
dc.subjectTRIBLOCK COPOLYMERS
dc.subjectPROTEIN RELEASE
dc.subjectGROWTH-FACTORS
dc.subjectTEMPERATURE
dc.subjectCHITOSAN
dc.subjectGELATION
dc.subjectSYSTEMS
dc.subjectWATER
dc.titleIn situ gelling hydrogels incorporating microparticles as drug delivery carriers for regenerative medicineen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1002/jps.21310
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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