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dc.contributor.authorBible, Ellen
dc.contributor.authorChau, David Y.S.
dc.contributor.authorAlexander, Morgan R.
dc.contributor.authorPrice, Jack
dc.contributor.authorShakesheff, Kevin M.
dc.contributor.authorModo, Michel
dc.date.accessioned2013-12-16T10:00:19Z
dc.date.available2013-12-16T10:00:19Z
dc.date.issued2009-06
dc.identifier.citationBible , E , Chau , D Y S , Alexander , M R , Price , J , Shakesheff , K M & Modo , M 2009 , ' The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles ' , Biomaterials , vol. 30 , no. 16 , pp. 2985-2994 . https://doi.org/10.1016/j.biomaterials.2009.02.012
dc.identifier.issn0142-9612
dc.identifier.otherPURE: 2585763
dc.identifier.otherPURE UUID: ab1200aa-92fd-4497-9453-9ae9b13f0b4f
dc.identifier.otherWOS: 000266148100003
dc.identifier.otherScopus: 63649083046
dc.identifier.urihttp://hdl.handle.net/2299/12314
dc.description.abstractStroke causes extensive cellular loss that leads to a disintegration of the afflicted brain tissue. Although transplanted neural stein cells can recover some of the function lost after stroke, recovery is incomplete and restoration of lost tissue is minimal. The challenge therefore is to provide transplanted cells with matrix support in order to optimise their ability to engraft the damaged tissue. We here demonstrate that plasma polymerised allylamine (ppAAm)-treated poly(D,L-lactic acid-co-glycolic acid) (PLGA) scaffold particles can act as a structural support for neural stem cells injected directly through a needle into the lesion cavity using magnetic resonance imaging-derived co-ordinates. Upon implantation, the neuro-scaffolds integrate efficiently within host tissue forming a primitive neural tissue. These neuro-scaffolds could therefore be a more advanced method to enhance brain repair. This study provides a substantial step in the technology development required for the translation of this approach. (C) 2009 Elsevier Ltd. All rights reserveden
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofBiomaterials
dc.subjectStroke
dc.subjectNeural stem cells
dc.subjectCell transplantation
dc.subjectPLGA
dc.subjectScaffold particle
dc.subjectTissue engineering
dc.subjectRETINAL PROGENITOR CELLS
dc.subjectENDOTHELIAL-CELLS
dc.subjectIN-VITRO
dc.subjectTISSUE
dc.subjectSCAFFOLDS
dc.subjectRECOVERY
dc.subjectGRAFTS
dc.subjectDIFFERENTIATION
dc.subjectPOLYMERS
dc.subjectSURVIVAL
dc.titleThe support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particlesen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2009-06
rioxxterms.versionSMUR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.biomaterials.2009.02.012
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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