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dc.contributor.authorVauzour, David
dc.contributor.authorVafeiadou, Katerina
dc.contributor.authorRodriguez-Mateos, Ana
dc.contributor.authorRendeiro, Catarina
dc.contributor.authorSpencer, Jeremy P. E.
dc.identifier.citationVauzour , D , Vafeiadou , K , Rodriguez-Mateos , A , Rendeiro , C & Spencer , J P E 2008 , ' The neuroprotective potential of flavonoids : a multiplicity of effects ' , Genes and Nutrition , vol. 3 , no. 3-4 , pp. 115-26 .
dc.identifier.otherPURE: 2234156
dc.identifier.otherPURE UUID: 34c09959-9c6e-4dfb-a861-e9f2448894c1
dc.identifier.otherPubMed: 18937002
dc.identifier.otherScopus: 70450223158
dc.description.abstractFlavonoids exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to promote memory, learning and cognitive function. These effects appear to be underpinned by two common processes. Firstly, they interact with critical protein and lipid kinase signalling cascades in the brain leading to an inhibition of apoptosis triggered by neurotoxic species and to a promotion of neuronal survival and synaptic plasticity. Secondly, they induce beneficial effects on the vascular system leading to changes in cerebrovascular blood flow capable of causing angiogenesis, neurogenesis and changes in neuronal morphology. Through these mechanisms, the consumption of flavonoid-rich foods throughout life holds the potential to limit neurodegeneration and to prevent or reverse age-dependent loses in cognitive performance. The intense interest in the development of drugs capable of enhancing brain function means that flavonoids may represent important precursor molecules in the quest to develop of a new generation of brain enhancing drugs.en
dc.relation.ispartofGenes and Nutrition
dc.titleThe neuroprotective potential of flavonoids : a multiplicity of effectsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionNutrition and Dietetics
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.typeJournal Article/Review

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