Show simple item record

dc.contributor.authorVafeiadou, Katerina
dc.contributor.authorVauzour, David
dc.contributor.authorRodriguez-Mateos, Ana
dc.contributor.authorWhiteman, Matthew
dc.contributor.authorWilliams, Robert J.
dc.contributor.authorSpencer, Jeremy P. E.
dc.date.accessioned2013-12-16T14:30:17Z
dc.date.available2013-12-16T14:30:17Z
dc.date.issued2008-10-15
dc.identifier.citationVafeiadou , K , Vauzour , D , Rodriguez-Mateos , A , Whiteman , M , Williams , R J & Spencer , J P E 2008 , ' Glial metabolism of quercetin reduces its neurotoxic potential ' , Archives of Biochemistry and Biophysics , vol. 478 , no. 2 , pp. 195-200 . https://doi.org/10.1016/j.abb.2008.07.014
dc.identifier.issn1096-0384
dc.identifier.otherPURE: 2234180
dc.identifier.otherPURE UUID: 71322926-d70b-4491-8523-f1adf629f2a6
dc.identifier.otherPubMed: 18675775
dc.identifier.otherScopus: 52049092512
dc.identifier.urihttp://hdl.handle.net/2299/12343
dc.description.abstractThe neuroprotective effects of flavonoids will ultimately depend on their interaction with both neuronal and glial cells. In this study, we show that the potential neurotoxic effects of quercetin are modified by glial cell interactions. Specifically, quercetin is rapidly conjugated to glutathione within glial cells to yield 2'-glutathionyl-quercetin, which is exported from cells but has significantly reduced neurotoxicity. In addition, quercetin underwent intracellular O-methylation to yield 3'-O-methyl-quercetin and 4'-O-methyl-quercetin, although these were not exported from glia at the same rate as the glutathionyl adduct. The neurotoxic potential of both quercetin and 2'-glutathionyl-quercetin paralleled their ability to modulate the pro-survival Akt/PKB and extracellular signal-regulated kinase (ERK) signalling pathways. These data were supported by co-culture investigation, where the neurotoxic effects of quercetin were significantly reduced when they were cultured alongside glial cells. We propose that glial cells act to protect neurons against the neurotoxic effects of quercetin and that 2'-glutathionyl-quercetin represents a novel quercetin metabolite.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofArchives of Biochemistry and Biophysics
dc.subjectAnimals
dc.subjectBiotransformation
dc.subjectCell Survival
dc.subjectCells, Cultured
dc.subjectMice
dc.subjectNeuroglia
dc.subjectNeuroprotective Agents
dc.subjectNeurotoxins
dc.subjectQuercetin
dc.titleGlial metabolism of quercetin reduces its neurotoxic potentialen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionFood Policy, Nutrition and Diet
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.abb.2008.07.014
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record