Show simple item record

dc.contributor.authorVauzour, David
dc.contributor.authorRavaioli, Giulia
dc.contributor.authorVafeiadou, Katerina
dc.contributor.authorRodriguez-Mateos, Ana
dc.contributor.authorAngeloni, Cristina
dc.contributor.authorSpencer, Jeremy P. E.
dc.date.accessioned2013-12-16T14:30:18Z
dc.date.available2013-12-16T14:30:18Z
dc.date.issued2008-08-15
dc.identifier.citationVauzour , D , Ravaioli , G , Vafeiadou , K , Rodriguez-Mateos , A , Angeloni , C & Spencer , J P E 2008 , ' Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1 : implications for Parkinson's disease and protection by polyphenols ' , Archives of Biochemistry and Biophysics , vol. 476 , no. 2 , pp. 145-51 . https://doi.org/10.1016/j.abb.2008.03.011
dc.identifier.issn1096-0384
dc.identifier.otherPURE: 2234211
dc.identifier.otherPURE UUID: 3816371a-a831-45a3-89fa-a8e251f8c645
dc.identifier.otherPubMed: 18394421
dc.identifier.otherScopus: 48049106637
dc.identifier.urihttp://hdl.handle.net/2299/12344
dc.description.abstractMechanisms of nigral cell injury in Parkinson's disease remain unclear, although a combination of increased oxidative stress, the formation of catecholamine-quinones and the subsequent formation of neurotoxic cysteinyl-catecholamine conjugates may contribute. In the present study, peroxynitrite was observed to generate both 2-S- and 5-S-cysteinyl-dopamine and a dihydrobenzothiazine species, DHBT-1, following the reaction of dopamine with l-cysteine. The formation of 5-S-cysteinyl-dopamine and DHBT-1 in the presence of peroxynitrite induced significant neuronal injury. Pre-treatment of cortical neurons with pelargonidin, quercetin, hesperetin, caffeic acid, the 4'-O-Me derivatives of catechin and epicatechin (0.1-3.0 microM) resulted in concentration dependant protection against 5-S-cysteinyl-dopamine-induced neurotoxicity. These data suggest that polyphenols may protect against neuronal injury induced by endogenous neurotoxins relevant to the aetiology of the Parkinson disease.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofArchives of Biochemistry and Biophysics
dc.subjectAnimals
dc.subjectCell Culture Techniques
dc.subjectCell Survival
dc.subjectCells, Cultured
dc.subjectCerebral Cortex
dc.subjectCulture Media, Serum-Free
dc.subjectDopamine
dc.subjectFlavonoids
dc.subjectMice
dc.subjectMolecular Structure
dc.subjectNeurons
dc.subjectParkinson Disease
dc.subjectPeroxynitrous Acid
dc.subjectPhenols
dc.subjectPolyphenols
dc.subjectTime Factors
dc.subjectTryptamines
dc.titlePeroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1 : implications for Parkinson's disease and protection by polyphenolsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionNutrition and Dietetics
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.abb.2008.03.011
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record