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dc.contributor.authorVafeiadou, Katerina
dc.contributor.authorVauzour, David
dc.contributor.authorSpencer, J. P. E.
dc.identifier.citationVafeiadou , K , Vauzour , D & Spencer , J P E 2007 , ' Neuroinflammation and its modulation by flavonoids ' , Endocrine, Metabolic & Immune Disorders - Drug Targets , vol. 7 , no. 3 , pp. 211-24 .
dc.identifier.otherPURE: 2234349
dc.identifier.otherPURE UUID: 1bc7b5f1-4012-426d-921c-690add2bf57e
dc.identifier.otherPubMed: 17897048
dc.identifier.otherScopus: 34848875051
dc.description.abstractThere is increasing evidence to suggest that neuroinflammatory processes contribute to the cascade of events that lead to the progressive neuronal damage observed in neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Therefore, treatment regimes aimed at modulating neuroinflammatory processes may act to slow the progression of these debilitating brain disorders. Recently, a group of dietary polyphenols known as flavonoids have been shown to exert neuroprotective effects in vivo and in neuronal cell models. In this review we discuss the evidence relating to the modulation of neuroinflammation by flavonoids. We highlight the evidence which suggests their mechanism of action involves: 1) attenuation of the release of cytokines, such as interleukin-1beta (IL-1beta and tumor necrosis factor-alpha (TNF-alpha); 2) an inhibitory action against inducible nitric oxide synthase (iNOS) induction and subsequent nitric oxide (NO(*)) production; 3) inhibition of the activation of NADPH oxidase and subsequent reactive oxygen species generation; 4) a capacity to down-regulate the activity of pro-inflammatory transcription factors such as nuclear factor-kappaB (NF-kappaB); and 5) the potential to modulate signalling pathways such as mitogen-activated protein kinase (MAPK) cascade. We also consider the potential of these dietary compounds to represent novel therapeutic agents by considering their metabolism in the body and their ability to access the brain via the blood brain barrier. Finally, we discuss future areas of study which are necessary before dietary flavonoids can be established as therapeutic agents against neuroinflammation.en
dc.relation.ispartofEndocrine, Metabolic & Immune Disorders - Drug Targets
dc.titleNeuroinflammation and its modulation by flavonoidsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionFood Policy, Nutrition and Diet
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.typeJournal Article/Review

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