Amanicadol, a pimarane-type diterpene from Phlomis amanica Vierch
Author
Yalçin, F.N.
Ersöz, T.
Çaliş, I.
Bedir, E.
Dönmez, A.A.
Stavri, M.
Gibbons, S.
Zloh, Mire
Attention
2299/12377
Abstract
Fractionation of the methanol extract of Phlomis amanica resulted in the isolation of a new pimarane type diterpene, amanicadol (1), together with the known glycosides lamiide, verbascoside (= acteoside), syringaresinol-4-O-β- glucoside, liriodendrin, syringin, and a caffeic acid ester, chlorogenic acid. The structure of the new compound was established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Molecular modeling studies on 1 were conducted and showed that it exhibited low conformational flexibility. Additionally, NMR chemical shifts were calculated for 1 in vacuo, and calculated values were in very close agreement with those found experimentally.