dc.contributor.author | Jones, R. A. | |
dc.contributor.author | Kotsakis, P. | |
dc.contributor.author | Johnson, T. S. | |
dc.contributor.author | Chau, David Y.S. | |
dc.contributor.author | Ali, S. | |
dc.contributor.author | Melino, G. | |
dc.contributor.author | Griffin, M. | |
dc.date.accessioned | 2013-12-17T13:30:25Z | |
dc.date.available | 2013-12-17T13:30:25Z | |
dc.date.issued | 2006-09 | |
dc.identifier.citation | Jones , R A , Kotsakis , P , Johnson , T S , Chau , D Y S , Ali , S , Melino , G & Griffin , M 2006 , ' Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth ' , Cell Death and Differentiation , vol. 13 , no. 9 , pp. 1442-1453 . https://doi.org/10.1038/sj.cdd.4401816 | |
dc.identifier.issn | 1350-9047 | |
dc.identifier.uri | http://hdl.handle.net/2299/12385 | |
dc.description.abstract | Administration of active TG2 to two different in vitro angiogenesis assays resulted in the accumulation of a complex extracellular matrix (ECM) leading to the suppression of endothelial tube formation without causing cell death. Matrix accumulation was accompanied by a decreased rate of ECM turnover, with increased resistance to matrix metallo-proteinase-1. Intratumor injection of TG2 into mice bearing CT26 colon carcinoma tumors demonstrated a reduction in tumor growth, and in some cases tumor regression. In TG2 knockout mice, tumor progression was increased and survival rate reduced compared to wild-type mice. In wild-type mice, an increased presence of TG2 was detectable in the host tissue around the tumor. Analysis of CT26 tumors injected with TG2 revealed fibrotic-like tissue containing increased collagen, TG2-mediated crosslink and reduced organized vasculature. TG2-mediated modulation of cell behavior via changes in the ECM may provide a new approach to solid tumor therapy. | en |
dc.format.extent | 12 | |
dc.language.iso | eng | |
dc.relation.ispartof | Cell Death and Differentiation | |
dc.subject | transglutaminase 2 | |
dc.subject | inhibition | |
dc.subject | angiogenesis | |
dc.subject | solid tumor | |
dc.subject | extracellular matrix | |
dc.subject | TISSUE TRANSGLUTAMINASE | |
dc.subject | CROSS-LINKING | |
dc.subject | EXTRACELLULAR-MATRIX | |
dc.subject | CELL-ADHESION | |
dc.subject | FIBRONECTIN | |
dc.subject | ENZYME | |
dc.subject | STABILIZATION | |
dc.subject | FIBROBLASTS | |
dc.subject | PROGRESSION | |
dc.subject | EXPRESSION | |
dc.title | Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.contributor.institution | Department of Pharmacy | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1038/sj.cdd.4401816 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |