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dc.contributor.authorMoreno, L.
dc.contributor.authorPerez-Vizcaino, F.
dc.contributor.authorHarrington, L.
dc.contributor.authorFaro, R.
dc.contributor.authorSturton, G.
dc.contributor.authorBarnes, P.J.
dc.contributor.authorMitchell, J.A.
dc.date.accessioned2013-12-17T14:00:22Z
dc.date.available2013-12-17T14:00:22Z
dc.date.issued2006-08-21
dc.identifier.citationMoreno , L , Perez-Vizcaino , F , Harrington , L , Faro , R , Sturton , G , Barnes , P J & Mitchell , J A 2006 , ' Pharmacology of airways and vessels in lung slices in situ : Role of endogenous dilator hormones ' , Respiratory Research , vol. 7 , 111 . https://doi.org/10.1186/1465-9921-7-111
dc.identifier.issn1465-9921
dc.identifier.otherPURE: 1745232
dc.identifier.otherPURE UUID: 1474a902-f4d1-4bb1-9e1e-b4307e8cfb13
dc.identifier.otherScopus: 33749470156
dc.identifier.urihttp://hdl.handle.net/2299/12389
dc.description© 2006 Moreno et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.description.abstractSmall airway and vessels play a critical role in chronic airway and pulmonary vascular diseases, but their pharmacology has not been well characterised. We have studied airway and vascular responses in rat lung slices and separately in vitro using myography. In lung slices, under basal conditions, acetylcholine contracted airways, but had no vascular effect. The thromboxane mimetic, U46619 contracted both vessels and airways. In the presence of U46619, acetylcholine dilated vessels, but further contracted airways, an effect that was blocked by the nitric oxide synthase inhibitor L-N-nitro-L-arginine or apamin plus charybdotoxin, which inhibit endothelial-derived hyperpolarising factor. Airway responses in lung slices were unaffected by L-Nnitro-L-arginine methyl ester, indomethacin or apamin plus charybdotoxin. By contrast, apamin plus charybdotoxin contracted bronchi studied in isolation. Our observations are the first to identify mechanisms of endothelium dependent dilations in precision cut lung slices and the potential for transverse hormonal communication between airways and vessels.en
dc.language.isoeng
dc.relation.ispartofRespiratory Research
dc.rightsOpen
dc.titlePharmacology of airways and vessels in lung slices in situ : Role of endogenous dilator hormonesen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=33749470156&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2006-08-21
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1186/1465-9921-7-111
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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