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dc.contributor.authorIravani, Mahmoud M.
dc.contributor.authorHaddon, C. O.
dc.contributor.authorCooper, J. M.
dc.contributor.authorJenner, P.
dc.contributor.authorSchapira, A. H.
dc.date.accessioned2013-12-18T13:30:12Z
dc.date.available2013-12-18T13:30:12Z
dc.date.issued2006-03
dc.identifier.citationIravani , M M , Haddon , C O , Cooper , J M , Jenner , P & Schapira , A H 2006 , ' Pramipexole protects against MPTP toxicity in non-human primates ' , Journal of Neurochemistry , vol. 96 , no. 5 , pp. 1315-1321 . https://doi.org/10.1111/j.1471-4159.2005.03625.x
dc.identifier.issn0022-3042
dc.identifier.otherPURE: 735296
dc.identifier.otherPURE UUID: 0289297b-0a5a-47d5-88ec-d79b4bc69498
dc.identifier.otherWOS: 000235332600009
dc.identifier.otherScopus: 33645101158
dc.identifier.otherORCID: /0000-0002-4905-9682/work/32997586
dc.identifier.urihttp://hdl.handle.net/2299/12407
dc.description.abstractThe neurotoxin MPTP induces nigral dopaminergic cell death in primates and produces a partial model of Parkinson's disease (PD). Pramipexole is a D-2/D-3 dopamine receptor agonist used in the symptomatic treatment of PD, and which also protects neuronal cells against dopaminergic toxins in vitro. We now demonstrate that pramipexole partially prevents MPTP toxicity in vivo in a primate species. Common marmosets were repeatedly treated with pramipexole either before, coincidentally with, or after low-dose MPTP treatment designed to induce a partial lesion of the substantia nigra. Animals pretreated with pramipexole had a significantly greater number of surviving tyrosine hydroxylase (TH) positive neurones in the pars compacta of the substantia nigra. Pramipexole pretreatment also prevented degeneration of striatal dopamine terminals. Treatment with pramipexole concurrently with MPTP or following MPTP did not prevent TH-positive cell loss. Pramipexole pretreatment appears to induce adaptive changes that protect against dopaminergic cell loss in primates.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofJournal of Neurochemistry
dc.subjectapoptosis
dc.subjectdopamine
dc.subjectdopamine agonist
dc.subjectmitochondria
dc.subjectneuroprotection
dc.subjectParkinson's disease
dc.subjectPARKINSONS-DISEASE
dc.subjectMETHYLPYRIDINIUM ION
dc.subjectLIPID-PEROXIDATION
dc.subjectDOPAMINE AGONIST
dc.subjectCELL-DEATH
dc.subjectIN-VITRO
dc.subjectMICE
dc.subject6-HYDROXYDOPAMINE
dc.subjectPROGRESSION
dc.subjectLEVODOPA
dc.titlePramipexole protects against MPTP toxicity in non-human primatesen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1111/j.1471-4159.2005.03625.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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