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dc.contributor.authorVafeiadou, Katerina
dc.contributor.authorHall, Wendy L.
dc.contributor.authorWilliams, Christine M.
dc.date.accessioned2013-12-18T14:00:23Z
dc.date.available2013-12-18T14:00:23Z
dc.date.issued2006-02
dc.identifier.citationVafeiadou , K , Hall , W L & Williams , C M 2006 , ' Does genotype and equol-production status affect response to isoflavones? Data from a pan-European study on the effects of isoflavones on cardiovascular risk markers in post-menopausal women ' , Procs of the Nutrition Society , vol. 65 , no. 1 , pp. 106-15 . https://doi.org/10.1079/PNS2005483
dc.identifier.issn0029-6651
dc.identifier.otherPURE: 2234661
dc.identifier.otherPURE UUID: e73182b7-3f54-4546-b798-fb63df1b74b5
dc.identifier.otherPubMed: 16441950
dc.identifier.otherScopus: 33144478520
dc.identifier.urihttp://hdl.handle.net/2299/12412
dc.description.abstractThe increase in CVD incidence following the menopause is associated with oestrogen loss. Dietary isoflavones are thought to be cardioprotective via their oestrogenic and oestrogen receptor-independent effects, but evidence to support this role is scarce. Individual variation in response to diet may be considerable and can obscure potential beneficial effects in a sample population; in particular, the response to isoflavone treatment may vary according to genotype and equol-production status. The effects of isoflavone supplementation (50 mg/d) on a range of established and novel biomarkers of CVD, including markers of lipid and glucose metabolism and inflammatory biomarkers, have been investigated in a placebo-controlled 2 x 8-week randomised cross-over study in 117 healthy post-menopausal women. Responsiveness to isoflavone supplementation according to (1) single nucleotide polymorphisms in a range of key CVD genes, including oestrogen receptor (ER) alpha and beta and (2) equol-production status has been examined. Isoflavones supplementation was found to have no effect on markers of lipids and glucose metabolism. Isoflavones improve C-reactive protein concentrations but do not affect other plasma inflammatory markers. There are no differences in response to isoflavones according to equol-production status. However, differences in HDL-cholesterol and vascular cell adhesion molecule 1 response to isoflavones v. placebo are evident with specific ERbeta genotypes. In conclusion, isoflavones have beneficial effects on C-reactive protein, but not other cardiovascular risk markers. However, specific ERbeta gene polymorphic subgroups may benefit from isoflavone supplementation.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofProcs of the Nutrition Society
dc.subjectBiological Markers
dc.subjectC-Reactive Protein
dc.subjectCardiovascular Diseases
dc.subjectEquol
dc.subjectEstrogen Receptor beta
dc.subjectFemale
dc.subjectGenotype
dc.subjectHumans
dc.subjectIsoflavones
dc.subjectPolymorphism, Single Nucleotide
dc.subjectPostmenopause
dc.subjectRisk Factors
dc.titleDoes genotype and equol-production status affect response to isoflavones? : Data from a pan-European study on the effects of isoflavones on cardiovascular risk markers in post-menopausal womenen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionNutrition and Dietetics
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2006-02
rioxxterms.versionofrecordhttps://doi.org/10.1079/PNS2005483
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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