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dc.contributor.authorChau, David Y.S.
dc.contributor.authorAgashi, K.
dc.contributor.authorShakesheff, K. M.
dc.date.accessioned2013-12-19T09:00:14Z
dc.date.available2013-12-19T09:00:14Z
dc.date.issued2008-09
dc.identifier.citationChau , D Y S , Agashi , K & Shakesheff , K M 2008 , ' Microparticles as tissue engineering scaffolds : manufacture, modification and manipulation ' , Materials Science and Technology , vol. 24 , no. 9 , pp. 1031-1044 . https://doi.org/10.1179/174328408X341726
dc.identifier.issn0267-0836
dc.identifier.otherPURE: 2585887
dc.identifier.otherPURE UUID: cb06aac9-29f1-4bb2-bf59-39eed56d3361
dc.identifier.otherWOS: 000259796000005
dc.identifier.otherScopus: 54949106667
dc.identifier.urihttp://hdl.handle.net/2299/12424
dc.description.abstractTissue engineering, a field which focusses on the replacement, repair and regeneration of damaged or diseased tissue by the application of biomaterials, cells and associated biological molecules, has advanced rapidly due to the intense demand for tissue substitutes. A key principle in tissue engineering involves growing the appropriate cells in vitro for the desired application before delivery into the body of a patient. The implantable devices, biological constructs or scaffolds, developed in tissue engineering aim to provide the initial architecture required for supporting the cells as well as define the micro and macrostructure of the final engineered product. Furthermore, these scaffolds may be exploited to release drugs and/or growth factors in a controlled manner, thus facilitating the repair and regeneration of the target tissue. Microparticles, spherical carrier scaffolds, have recently received extensive interest for their potential therapeutic applications in a diverse range of clinical and regenerative medical settings. Not only can these versatile subunits be used as cell culture scaffolds, their innate structure reduces the degradation of encapsulated biologically active molecules and also allows their exploitation as a localised injectable delivery system. The purpose of the present article is to review the tissue engineering applications of these microparticles and to provide a brief overview of the critical factors considered during their formulation and use - including the range of materials used and the different modification protocols and technologies exploited to improve and enhance their mechanical properties and biocompatibility for regenerative medicine.en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofMaterials Science and Technology
dc.subjectbiomaterial
dc.subjectdrug delivery
dc.subjectmicroparticles
dc.subjectmicrospheres
dc.subjectpolymers
dc.subjecttissue engineering
dc.subjectSINTERED MICROSPHERE SCAFFOLDS
dc.subjectSUPERCRITICAL CARBON-DIOXIDE
dc.subjectCONTROLLED DRUG-RELEASE
dc.subjectLACTIDE-CO-GLYCOLIDE
dc.subjectIN-VITRO EVALUATION
dc.subjectCELL-ADHESION
dc.subjectBIODEGRADABLE MICROSPHERES
dc.subjectMECHANICAL-PROPERTIES
dc.subjectSURFACE MODIFICATION
dc.subjectSOLVENT EVAPORATION
dc.titleMicroparticles as tissue engineering scaffolds : manufacture, modification and manipulationen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2008-09
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1179/174328408X341726
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue


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