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dc.contributor.authorIngram, R.J.
dc.contributor.authorBartlett, A.
dc.contributor.authorMarriott, C.
dc.contributor.authorWhitfield, P.J.
dc.contributor.authorBrown, Marc
dc.date.accessioned2014-01-15T17:30:32Z
dc.date.available2014-01-15T17:30:32Z
dc.date.issued2002-04
dc.identifier.citationIngram , R J , Bartlett , A , Marriott , C , Whitfield , P J & Brown , M 2002 , ' Dimethicone barrier cream prevents infection of human skin by Schistosome cercariae : Evidence from Franz cell studies ' , Journal of Parasitology , vol. 88 , no. 2 , pp. 399-402 .
dc.identifier.issn0022-3395
dc.identifier.otherPURE: 629193
dc.identifier.otherPURE UUID: 63c70adc-c6f9-4df8-8f85-5cbd6837db36
dc.identifier.otherWOS: 000175294300033
dc.identifier.otherScopus: 0036246369
dc.identifier.urihttp://hdl.handle.net/2299/12546
dc.description.abstractOne approach to the prevention of schistosomiasis is the use of topical formulations to inhibit cercalial penetration of skin. A number of formulations containing either cercaricidal ingredients or components designed to inhibit penetration have been studied, but with variable results. Such studies have rarely considered the persistence of inhibitory effects through time, and to date, there have been no systematic investigations of barrier formulations. The aim of this study was to use Franz cells to investigate the effect of such barrier creams on the penetration of S. mansoni cercariae into human skin. The results show that a single application of it barrier cream based on dimethicone offers a high level of protection against penetration that is sustained for at least 48 hr.en
dc.format.extent4
dc.language.isoeng
dc.relation.ispartofJournal of Parasitology
dc.subjectPROTEASE INHIBITORS
dc.subjectMANSONI-CERCARIAE
dc.subjectINVASION
dc.titleDimethicone barrier cream prevents infection of human skin by Schistosome cercariae : Evidence from Franz cell studiesen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2002-04
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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