dc.contributor.author | Ingram, R.J. | |
dc.contributor.author | Bartlett, A. | |
dc.contributor.author | Marriott, C. | |
dc.contributor.author | Whitfield, P.J. | |
dc.contributor.author | Brown, Marc | |
dc.date.accessioned | 2014-01-15T17:30:32Z | |
dc.date.available | 2014-01-15T17:30:32Z | |
dc.date.issued | 2002-04 | |
dc.identifier.citation | Ingram , R J , Bartlett , A , Marriott , C , Whitfield , P J & Brown , M 2002 , ' Dimethicone barrier cream prevents infection of human skin by Schistosome cercariae : Evidence from Franz cell studies ' , Journal of Parasitology , vol. 88 , no. 2 , pp. 399-402 . | |
dc.identifier.issn | 0022-3395 | |
dc.identifier.other | PURE: 629193 | |
dc.identifier.other | PURE UUID: 63c70adc-c6f9-4df8-8f85-5cbd6837db36 | |
dc.identifier.other | WOS: 000175294300033 | |
dc.identifier.other | Scopus: 0036246369 | |
dc.identifier.uri | http://hdl.handle.net/2299/12546 | |
dc.description.abstract | One approach to the prevention of schistosomiasis is the use of topical formulations to inhibit cercalial penetration of skin. A number of formulations containing either cercaricidal ingredients or components designed to inhibit penetration have been studied, but with variable results. Such studies have rarely considered the persistence of inhibitory effects through time, and to date, there have been no systematic investigations of barrier formulations. The aim of this study was to use Franz cells to investigate the effect of such barrier creams on the penetration of S. mansoni cercariae into human skin. The results show that a single application of it barrier cream based on dimethicone offers a high level of protection against penetration that is sustained for at least 48 hr. | en |
dc.format.extent | 4 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Parasitology | |
dc.subject | PROTEASE INHIBITORS | |
dc.subject | MANSONI-CERCARIAE | |
dc.subject | INVASION | |
dc.title | Dimethicone barrier cream prevents infection of human skin by Schistosome cercariae : Evidence from Franz cell studies | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Pharmacy | |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.contributor.institution | Pharmaceutics | |
dc.contributor.institution | Skin and Nail Group | |
dc.contributor.institution | Airway Group | |
dc.contributor.institution | Bioadhesive Drug Delivery Group | |
dc.contributor.institution | Nanopharmaceutics | |
dc.contributor.institution | Pharmaceutical Analysis and Product Characterisation | |
dc.description.status | Peer reviewed | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |