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dc.contributor.authorLim, S. T.
dc.contributor.authorForbes, B.
dc.contributor.authorBerry, D. J.
dc.contributor.authorMartin, Gary P.
dc.contributor.authorBrown, Marc
dc.date.accessioned2014-01-16T10:00:36Z
dc.date.available2014-01-16T10:00:36Z
dc.date.issued2002-01
dc.identifier.citationLim , S T , Forbes , B , Berry , D J , Martin , G P & Brown , M 2002 , ' In vivo evaluation of novel hyaluronan/chitosan microparticulate delivery systems for the nasal delivery of gentamicin in rabbits ' , International Journal of Pharmaceutics , vol. 231 , no. 1 , pp. 73-82 . https://doi.org/10.1016/S0378-5173(01)00873-0
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 629277
dc.identifier.otherPURE UUID: b27500c8-b9a0-4ba3-ac39-a1d2b3c02393
dc.identifier.otherWOS: 000173198600009
dc.identifier.otherScopus: 0035185671
dc.identifier.urihttp://hdl.handle.net/2299/12551
dc.description.abstractBiodegradable microparticles containing gentamicin were prepared using chitosan hydroglutamate (CH), hyaluronic acid (HA) and a combination Of both polymers by a solvent evaporation method. These formulations were administered nasally via an insufflator. Gentamicin was also administered nasally into rabbits as a solution and powder (a physical mixture of gentamicin and lactose), intravenously (IV) and intramuscularly (IM). The resultant serum levels of gentamicin were determined by Fluorescence Polarisation Immunoassay (FPlA). The bioavailability of gentamicin was poor when administered as a nasal solution (1.1%) and dry powder (2.1%) when compared with IV. However, the microparticulate systems composed of CH and HA/CH considerably enhanced the bioavailability of gentamicin (31.4 and 42.9%, respectively,) with HA microparticles inducing a less significant enhancement (23.3%). Previous in vitro dissolution and frog palate studies indicated that these microparticulate formulations were all mucoadhesive and demonstrated prolonged drug release. Such findings were translated into an increase in the bioavailability of gentamicin when compared with a simple nasal solution in vivo. When HA and CH were combined in the HA/CH formulation, the polymers appeared to improve the absorption of incorporated gentamicin synergistically in comparison to the individual polymers, suggesting a promising nasal delivery system. (C) 2002 Elsevier Science B.V. All rights reserved.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.subjectgentamicin
dc.subjecthyaluronan
dc.subjectchitosan
dc.subjectnasal delivery
dc.subjectmicroparticles
dc.subjectHYALURONIC-ACID
dc.subjectABSORPTION
dc.subjectINSULIN
dc.subjectMICROSPHERES
dc.subjectRATS
dc.subjectCHITOSAN
dc.subjectFORMULATIONS
dc.subjectENHANCEMENT
dc.subjectPOLYMERS
dc.subjectPOWDER
dc.titleIn vivo evaluation of novel hyaluronan/chitosan microparticulate delivery systems for the nasal delivery of gentamicin in rabbitsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2002-01
rioxxterms.versionofrecordhttps://doi.org/10.1016/S0378-5173(01)00873-0
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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