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dc.contributor.authorDass, B.
dc.contributor.authorIravani, Mahmoud M.
dc.contributor.authorJackson, M. J.
dc.contributor.authorEngber, T. M.
dc.contributor.authorGaldes, A.
dc.contributor.authorJenner, P.
dc.date.accessioned2014-01-16T10:30:39Z
dc.date.available2014-01-16T10:30:39Z
dc.date.issued2002
dc.identifier.citationDass , B , Iravani , M M , Jackson , M J , Engber , T M , Galdes , A & Jenner , P 2002 , ' Behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets ' , Neuroscience , vol. 114 , no. 1 , pp. 99-109 . https://doi.org/10.1016/S0306-4522(02)00214-2
dc.identifier.issn0306-4522
dc.identifier.otherPURE: 735753
dc.identifier.otherPURE UUID: e0712cfe-86db-4840-a559-4e5e3281b6b4
dc.identifier.otherWOS: 000178011200011
dc.identifier.otherScopus: 0037130581
dc.identifier.otherORCID: /0000-0002-4905-9682/work/32997600
dc.identifier.urihttp://hdl.handle.net/2299/12557
dc.description.abstractSonic hedgehog (SHH) has trophic actions on dopaminergic cell cultures and protects them from MPP+ toxicity but its in vivo actions have not been explored. We now investigate the effects of unilateral supranigral administration of SHH on nigro-striatal function in 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine-treated common marmosets, SHH (0.1 or 1.0 mug) or vehicle was stereotaxically injected into the region of the right substantia nigra twice with an interval of 5 weeks between administrations. The first or second administration of low dose SHH (0.1 mug) did not significantly improve motor disability or locomotor activity compared to time-matched vehicle-treated animals. There was. however, an approximately 30% improvement in both motor disability and locomotor activity following the first administration of high dose SHH (1.0 mug). No further improvements occurred following the second high dose SHH treatment, Acute oral administration of L-3,4-dihydroxyphenylalanine (L-DOPA) produced a smaller increase in locomotor activity and greater reversal of motor disability in animals treated with SHH than occurred in vehicle-treated common marmosets. In the substantia nigra pars compacta. ipsilateral to SHH administration, the number of tyrosine hydroxylase-positive neurones was increased by 21% (P>0.05) and 57% (P>0.05) in low and high dose SHH groups respectively compared to the untreated contralateral hemisphere, There was no difference in the number of glial fibrillary acidic protein-positive cells. SHH may improve nigro-striatal function by restoring tyrosine hydroxylase positivity. This is reflected by an improvement in basal disability and a reduction in the lesion-induced response to L-DOPA. (C) 2002 IBRO, Published by Elsevier Science Ltd. All rights reserved.en
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofNeuroscience
dc.subjectParkinson's disease
dc.subjectneurotrophic factors
dc.subjectsonic hedgehog
dc.subject1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
dc.subjectcommon marmoset
dc.subjectFIBROBLAST GROWTH-FACTOR
dc.subjectNEUROTROPHIC FACTOR
dc.subjectPARKINSONS-DISEASE
dc.subjectL-DOPA
dc.subjectTRANSDUCING HEDGEHOG
dc.subjectDOPAMINERGIC-NEURONS
dc.subjectNEURAL-TUBE
dc.subjectSURVIVAL
dc.subjectMONKEYS
dc.subjectBDNF
dc.titleBehavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosetsen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/S0306-4522(02)00214-2
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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