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dc.contributor.authorMartin, Gary P.
dc.contributor.authorLadenheim, D.
dc.contributor.authorMarriott, C.
dc.contributor.authorHollingsbee, D.A.
dc.contributor.authorBrown, Marc
dc.date.accessioned2014-01-22T15:00:28Z
dc.date.available2014-01-22T15:00:28Z
dc.date.issued2000-01
dc.identifier.citationMartin , G P , Ladenheim , D , Marriott , C , Hollingsbee , D A & Brown , M 2000 , ' The influence of hydrocolloid patch composition on the bioavailability of triamcinolone acetonide in humans ' , Drug Development and Industrial Pharmacy , vol. 26 , no. 1 , pp. 35-43 .
dc.identifier.issn0363-9045
dc.identifier.otherPURE: 631338
dc.identifier.otherPURE UUID: 7ee9f07e-b593-4b85-bba9-55d07c6d038b
dc.identifier.otherWOS: 000084768500006
dc.identifier.otherScopus: 0033979357
dc.identifier.urihttp://hdl.handle.net/2299/12614
dc.description.abstractTriamcinolone acetonide (TACA) is a corticosteroid; it is used in the systemic and topical treatment of a variety of inflammatory conditions, including eczema and psoriasis. Conventionally, for topical use, the drug is formulated in a cream or ointment. However, it has been observed in vitro that percutaneous penetration of corticosteroids can be influenced by hydrocolloid patches. Corticosteroids produce a pallor or blanching when applied to the skin that correlates with anti-inflammatory activity; this property has been used extensively as a bioassay. The aim of this study therefore was to evaluate the occlusive properties of a range of hydrocolloid patches containing TACA on the drug's penetration in vivo using visual assessment and a graded multiple measurement. The in vivo hydration of these dermatological patches was also investigated. Statistical analysis of the weight gains of patches containing either NaCMC 39% or pectin 39% showed that there was a significant difference in the rates of hydration of the two types of patch (p < .005). An increase in application time of the hydrocolloid patches allowed more TACA to be released, which was illustrated by an increase in both the maximum percentage total possible score (%TPS) values and AUC, although changes in the hydrocolloid composition did not significantly alter the blanching response. All of the patches adhered well, were unobtrusive to the normal activity of the wearers, and showed great potential for the convenient, localized, prolonged delivery of drugs to the skin.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofDrug Development and Industrial Pharmacy
dc.subjectblanching
dc.subjectcorticosteroid
dc.subjectocclusion
dc.subjecttopical
dc.subjectTOPICAL CORTICOSTEROID PREPARATIONS
dc.subjectEPIDERMAL WATER-LOSS
dc.subjectCOMPARATIVE BIO-AVAILABILITY
dc.subjectVASOCONSTRICTOR ASSAYS
dc.subjectDERMATOLOGICAL PATCH
dc.subjectSKIN
dc.subjectPENETRATION
dc.subjectOCCLUSION
dc.subjectPSORIASIS
dc.subjectSTEROIDS
dc.titleThe influence of hydrocolloid patch composition on the bioavailability of triamcinolone acetonide in humansen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2000-01
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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